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. 2023 Mar 2;14:1115226. doi: 10.3389/fphar.2023.1115226

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Copyright © 2023 Chen, Li and Du.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The multiple roles of KLF15 in liver disease are outlined. First, KLF15 plays an important role in acute liver injury, including the regulation of TIBL, ALT, AST, and inflammatory factors (COX-2, MCP-1, IL-1β, and TNF-α). With respect to hepatitis B virus, KLF15 positively regulates HBV major surface and core promoters, HBsAg and the core protein, as well as HBV DNA replication. Finally, the miR-431-5p/KLF15/p53 signaling pathway is a potential therapeutic target in autoimmune hepatitis.