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. 2023 Mar 2;10:1138690. doi: 10.3389/fmed.2023.1138690

Figure 4.

Figure 4

FRA protein detection by immunohistochemistry in fallopian tubal, ovarian endometriosis, endosalpingiosis, and endometrial tissue sections. Representative IHC stains of FRA showed strong diffuse FRA expression in the fallopian tube (left column, A,E,I), ovarian endometriosis (left mid, B,F,J), and ovarian endosalpingiosis (right mid, C,G,K), but only focal and weak staining was observed in a case of proliferative endometrium (right column, D,H,L). FRA staining was mainly cytoplasmic. Membranous stains can be seen when the staining intensity is moderate (E) and luminal stains are more prominent when stains become weak or moderate and magnified (I,L). Histologic H&E sections are arranged on the top panel. FRA expression in the fallopian tube is illustrated in panels (E,I), where I (200x) represents the magnification of part of E (100x). FRA expression in 2 ovarian endometriosis cases, with one showing high (F, 100x) and one showing intermediate (J, 100x) FRA expression levels. FRA expression in endosalpingiosis is shown in panels G (100x) and K (200x). Focal glandular with a mainly luminal pattern is seen in an endometrial sample (H, 100x; L, 200x).