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. 2023 Mar 2;10:1118738. doi: 10.3389/fcvm.2023.1118738

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Copyright © 2023 Abbas, Olivere, Padgett, Schmidt, Gilmore, McCord, Southerland, McClung and Kontos.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Myoblasts isolated from Pax7-depleted muscle fail to differentiate under hypoxic conditions and display increased adipogenesis. (A) Pax7^WT myoblasts in differentiation medium expressed myosin heavy chain (MHC) under hypoxia whereas Pax7^Δ cells failed to fuse and did not express the early differentiation marker myogenin or MHC. (B) When grown in adipogenic medium, Pax7^Δ myoblasts had a higher propensity to form oil red O⁺ lipid droplets. Similar results were observed in three independent experiments. Scale bars = 100 μm.