Table 2.
Association of genetic mutations with baseline characteristics in CN-AML patients
| Characteristics | NPM1 | FLT3-ITD | CEBPA | ||||||
|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
|||||||
| Wild (n=101) | Mutant (n=50) | p-value | Negative (n=115) | Positive (n=36) | p-value | Wild (n=128) | Mutant (n=23) | p-value | |
| Age at diagnosis (years) | 0.48 | 0.68 | 0.86 | ||||||
| Median | 36 | 36.5 | 36 | 36.5 | 37 | 35 | |||
| Range | 18-74 | 18-75 | 18-74 | 18-75 | 18-75 | 18-74 | |||
| Sex, n (%) | 0.066 | 0.16 | 0.12 | ||||||
| Male | 70 (69.3) | 27 (54) | 70 | 27 | 79 | 18 | |||
| Female | 34 (33.66) | 23 (46) | 45 | 9 | 49 | 5 | |||
| Hemoglobin (g/dL) | 0.96 | 0.67 | 0.23 | ||||||
| Median | 8 | 7.8 | 8 | 7.55 | 7.7 | 8.9 | |||
| Range | 2.8-14 | 3.5-15.4 | 2.8-15.4 | 3.8-13.7 | 2.8-17.3 | 6.5-13 | |||
| Platelets (× 109/L) | 0.09 | 0.45 | 0.12 | ||||||
| Median | 52.5 | 69 | 54 | 55 | 57 | 37 | |||
| Range | 1-73 | 15-283 | 1-73 | 6.3-283 | 1-73 | 7-141 | |||
| WBC (× 109/L) | 0.20 | 0.62 | |||||||
| Median | 22.55 | 28.25 | 22.8 | 23.2 | 0.71 | 20.5 | 35.1 | ||
| Range | 0.24-411 | 0.76-282 | 0.24-411 | 4.4-278 | 2.4-411 | 0.68-242 | |||
| Peripheral blood blast, (%) | 0.93 | 0.02 | 0.93 | ||||||
| Median | 61 | 75 | 63 | 55 | 63 | 63 | |||
| Range | 2-98 | 7-96 | 2-98 | 4-96 | 2-98 | 30-95 | |||
| Bone marrow blasts, (%) | 0.36 | 0.22 | 0.87 | ||||||
| Median | 75 | 77.5 | 75 | 77 | 80 | 75 | |||
| Range | 24-95 | 60-95 | 60-95 | 24-95 | 60-95 | 40-95 | |||