Table 1.
Distribution of pairs predicted to be alloreactive according each model.
| Genoidentical N=43 (55,1%) |
Haploidentical N=35 (44,9%) |
p* | |||
|---|---|---|---|---|---|
| N | %/mean | N | %/mean | ||
| LIGAND-LIGAND | |||||
| Bw4/Bw6 | 0,0004 | ||||
| HVG mismatch | 0 | 0,0 | 6 | 17,1 | |
| No mismatch | 43 | 100,0 | 26 | 74,3 | |
| GVH mismatch | 0 | 0,0 | 3 | 8,6 | |
| Bw IPD | 0,0025 | ||||
| HVG mismatch | 0 | 0,0 | 4 | 11,4 | |
| No mismatch | 43 | 100,0 | 28 | 80,0 | |
| GVH mismatch | 0 | 0,0 | 3 | 8,6 | |
| C1/C2 | <0,0001 | ||||
| HVG mismatch | 0 | 0,0 | 4 | 11,4 | |
| No mismatch | 43 | 100,0 | 24 | 68,6 | |
| GVH mismatch | 0 | 0,0 | 7 | 20,0 | |
| L/L synthesis | <0,0001 | ||||
| HVG mismatch in at least one model | 0 | 0,0 | 10 | 28,6 | |
| No mismatch in any model | 43 | 100,0 | 14 | 40,0 | |
| GVH mismatch in at least one model | 0 | 0,0 | 10 | 28,6 | |
| HVG mismatch + GVH mismatch | 0 | 0,0 | 1 | 2,9 | |
| RECEPTOR-LIGAND | |||||
| 2DL1-C2 | |||||
| No | 35 | 81,4 | 21 | 60,0 | 0,0368 |
| Yes | 8 | 18,6 | 14 | 40,0 | |
| 3DL1-Bw4 | |||||
| No | 29 | 67,4 | 30 | 85,7 | 0,0615 |
| Yes | 14 | 32,6 | 5 | 14,3 | |
| 3DL2-A3/A11 | 0,9440 | ||||
| No | 20 | 46,5 | 16 | 45,7 | |
| Yes | 23 | 53,5 | 19 | 54,3 | |
| 2DL2/3-C1 | 0,5287 | ||||
| No | 38 | 88,4 | 29 | 82,9 | |
| Yes | 5 | 11,6 | 6 | 17,1 | |
| R-L quantitative synthesis | 0,2891 | ||||
| 0 | 8 | 18,6 | 6 | 17,1 | |
| 1 | 20 | 46,5 | 17 | 48,6 | |
| 2 | 15 | 34,9 | 9 | 25,7 | |
| 3 | 0 | 0,0 | 3 | 8,6 | |
| R-L qualitative synthesis | 0,8671 | ||||
| No | 8 | 18,6 | 6 | 17,1 | |
| Yes | 35 | 81,4 | 29 | 82,9 | |
| EDUCATIONAL | |||||
| Educ-2DL1 | 0,0088 | ||||
| Uneducated (without 2DL1) | 10 (2) | 23,3 | 14 (2) | 40,0 | |
| No predicted alloreactivity | 33 | 76,7 | 17 | 48,6 | |
| Predicted alloreactivity | 0 | 0,0 | 4 | 11,4 | |
| Educ-2DL2/3 | 0,1853 | ||||
| Uneducated | 5 | 11,6 | 4 | 11,4 | |
| No predicted alloreactivity | 38 | 88,4 | 28 | 80,0 | |
| Predicted alloreactivity | 0 | 0,0 | 3 | 8,6 | |
| Educ-3DL1 | 0,1465 | ||||
| Uneducated (without 3DL1) | 17 (3) | 39,5 | 8 (2) | 22,9 | |
| No predicted alloreactivity | 26 | 60,5 | 26 | 74,3 | |
| Predicted alloreactivity | 0 | 0,0 | 1 | 2,9 | |
| Educ-3DL2 | 0,1298 | ||||
| Uneducated | 23 | 53,5 | 24 | 68,6 | |
| No predicted alloreactivity | 20 | 46,5 | 10 | 28,6 | |
| Predicted alloreactivity | 0 | 0,0 | 1 | 2,9 | |
| Educ-DL synthesis | 0,0004 | ||||
| 0 | 43 | 100,0 | 26 | 74,3 | |
| 1 | 0 | 0,0 | 9 | 25,7 | |
| Educ-2DS1 | 0,2627 | ||||
| No predicted alloreactivity | 34 | 79,1 | 31 | 88,6 | |
| Predicted alloreactivity | 9 | 20,9 | 4 | 11,4 | |
| DONORS’ HAPLOTYPES | |||||
| B-pattern | 0,9609 | ||||
| 0 | 11 | 25,6 | 11 | 31,4 | |
| 1 | 18 | 41,9 | 12 | 34,3 | |
| 2 | 9 | 20,9 | 8 | 22,9 | |
| 3 | 4 | 9,3 | 3 | 8,6 | |
| 4 | 1 | 2,3 | 1 | 2,9 | |
| Cen-B | 0,7159 | ||||
| 0 | 17 | 39,5 | 14 | 40,0 | |
| 1 | 19 | 44,2 | 13 | 37,1 | |
| 2 | 7 | 16,3 | 8 | 22,9 | |
| Tel-B | 0,8051 | ||||
| 0 | 27 | 62,8 | 25 | 71,4 | |
| 1 | 13 | 30,2 | 8 | 22,9 | |
| 2 | 3 | 7,0 | 2 | 5,7 | |
| KIR-B content score | 0,6608 | ||||
| Neutral | 29 | 67,4 | 23 | 65,7 | |
| Better | 7 | 16,3 | 4 | 11,4 | |
| Best | 7 | 16,3 | 8 | 22,9 | |
| GENE-GENE | |||||
| Donor’s aKIR | 0,4623 | ||||
| 0 aKIR | 5 | 11,6 | 5 | 14,3 | |
| 1 or 2 aKIR | 15 | 34,9 | 16 | 45,7 | |
| Greater/equal 3 aKIR | 23 | 53,5 | 14 | 40,0 | |
| R-D aKIR | 0,8593 | ||||
| Missing | 2 | 3 | |||
| No. of recipient’s aKIR > No of donor’s aKIR | 11 | 26,8 | 10 | 31,3 | |
| No. of recipient’s aKIR = No of donor’s aKIR | 21 | 51,2 | 16 | 50,0 | |
| Donor has 1 or 2 aKIR more than recipient | 4 | 9,8 | 4 | 12,5 | |
| Donor has ≥ 3 aKIR more than recipient | 5 | 12,2 | 2 | 6,3 | |
| Donor’s iKIR | 0,9094 | ||||
| 2 or 3 iKIR | 13 | 30,2 | 11 | 31,4 | |
| Greater/equal 4 iKIR | 30 | 69,8 | 24 | 68,6 | |
| R-D iKIR | 0,5071 | ||||
| Missing | 2 | 3 | |||
| No. of recipient’s iKIR > No of donor’s iKIR | 13 | 31,7 | 11 | 34,4 | |
| No. of recipient’s iKIR = No of donor’s iKIR | 17 | 41,5 | 16 | 50,0 | |
| Donor has 1 or 2 iKIR more than recipient | 11 | 26,8 | 5 | 15,6 | |
| ALLELIC POLYMORPHISM | |||||
| 3DL1 expression | 0,7294 | ||||
| Missing | 1 | 5 | |||
| Null or absent | 5 | 11,9 | 3 | 10,0 | |
| Low | 5 | 11,9 | 6 | 20,0 | |
| High | 32 | 76,2 | 21 | 70,0 | |
| 2DL1 R/C dimorphism | 0,8199 | ||||
| Missing | 0 | 4 | |||
| No R allele | 6 | 14,0 | 5 | 16,1 | |
| At least one R allele | 34 | 79,1 | 25 | 80,6 | |
| Ambiguous | 3 | 7,0 | 1 | 3,2 | |
| -21 B dimorphism | 0,9455 | ||||
| Donor TT | 24 | 55,8 | 21 | 60,0 | |
| Donor MT | 14 | 32,6 | 11 | 31,4 | |
| Donor MM | 5 | 11,6 | 3 | 8,6 | |