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. 2023 Mar 15;13:4326. doi: 10.1038/s41598-023-31281-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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SkQ1, administered 1 min after the end of cold exposure, increased survival and accelerated the return to normal body temperature. Mice were exposed to − 20 °C for 1 h and then returned to room temperature. (A) Without SkQ1. (B) SkQ1 (1.5 μmol/kg) was introduced intraperitoneally 1 min after cessation of cooling. The solid curves show the body temperature of mice that died after the cold shock (8 out of 10 in (A) and 3 out of 10 in (B)); dashed curves, mice survived after cooling.