Table 4.

Breakdown of results across four survival analyses.

	C9orf72	CAV Enhancer Mutations	CAV+ ALS	CAV− ALS		Hazard Ratio (95% CI)	Standard Error	p-value
1		CAV1 and CAV2	44	5,943	CAV	0.694 (0.487, 0.988)	0.180	0.043*
					Age of onset	1.000	0.000	<0.001***
					Sex at birth	1.075 (1.013, 1.141)	0.031	0.018*
2		CAV1 and CAV2	42	5,589	CAV	0.674 (0.468, 0.971)	0.186	0.034*
					Age of onset	1.000	0.000	<0.001***
					Sex at birth	1.085 (1.020, 1.155)	0.032	0.010**
3		CAV1	33	5,589	CAV	0.729 (0.484, 1.099)	0.201	0.131
					Age of onset	1.000	0.000	<0.001***
					Sex at birth	1.084 (1.019, 1.154)	0.032	0.011*
4		CAV2	9	5,589	CAV	0.523 (0.235, 1.164)	0.409	0.112
					Age of onset	1.000	0.000	<0.001***
					Sex at birth	1.088 (1.022, 1.158)	0.032	0.008**

The left side of the table displays the inclusion criteria of each analysis, and the right side displays the results. The first two columns specify whether samples with a C9orf72 mutation have been included (green tick) or excluded (red cross). CAV+ denotes the number of samples with CAV1/2 enhancer mutations, and CAV- indicates the sample size of those without CAV1/2 enhancer mutations. *p < 0.05; **p < 0.01; ^***p < 0.001.