Table 6.

The left side of the table describes the inclusion criteria and CAV+/CAV− sample size; the right size shows results from age of onset analyses using Cox proportional hazards and linear regression models; ^***p < 0.001.

	C9orf72	CAV mutations	CAV+ ALS	CAV− ALS		Hazard Ratio (95% CI)	Standard Error	p-value
1		CAV1 and CAV2	44	5,943	CAV	1.034 (0.826, 1.296)	0.115	0.768
					Sex at birth	0.864 (0.820, 0.910)	0.026	<0.001***
2		CAV1 and CAV2	42	5,589	CAV	1.036 (0.823, 1.303)	0.117	0.764
					Sex at birth	0.859 (0.814, 0.906)	0.027	<0.001***
3		CAV1	33	5,589	CAV	1.078 (0.765, 1.518)	0.175	0.669
					Sex at birth	0.858 (0.813, 0.905)	0.027	<0.001***
4		CAV2	9	5,589	CAV	0.864 (0.449, 1.662)	0.334	0.662
					Sex at birth	0.857 (0.813, 0.905)	0.027	<0.001***
Linear Regression						t-value	Standard Error	p-value
5		CAV1 and CAV2	44	5,943	CAV	−0.425	1.916	0.671***
					Sex at birth	6.476	0.334	<0.001***