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Mutation profile of the SARS-CoV-2 genome in Latin America and worldwide from the beginning of the pandemic to January 2022. (A) Mutation frequency in the region S1 encoding the spike protein of the SARS-CoV-2 viral genome. Colors represent the intervals for the absolute mutation number. (B) Mutation rate of the SARS-CoV-2 genomes during the pandemic, including distinct genotypes (colors) and the approach to estimate consensus rate (black line).
