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Mechanism of HER2 targeted drugs and EGFR family in breast cancer. Homo- or heterodimers of HER2 lead to the phosphorylation of tyrosine kinase residues in domain IV and regulate various downstream signaling pathways. HER, Human epidermal growth factor receptor. EGFR, epidermal growth factor receptor. T-DM1, trastuzumab emtansine.
