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Recommendations for HER2-positive MBC (Giordano et al., 2022). After the failure of multiple lines of treatment, there is insufficient evidence to recommend one regimen over another due to the lack of head-to-head trials. HER2, Human epidermal growth factor receptor 2. T-DM1, trastuzumab emtansine. T-Dxd, trastuzumab deruxtecan.
