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. 2023 Mar 2;11:1111424. doi: 10.3389/fcell.2023.1111424

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Copyright © 2023 Romero-Guevara, Nicolaou, Petracca, Shaheed, Sutton, Frangou, Afami, Kyriacou, Ioannides and Xinaris.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proteomic analysis comparison of hiPSC-derived D14 podocytes from Alport disease (AS1 and AS3) and normal patients (LT) cell lines. In (A), the Venn diagram highlighting the differentially expressed proteins from each comparison and those commonly affected in both Alport cell lines. The enriched KEGG pathways identified from the differentially expressed proteins between AS3 and LT (B), AS1 and LT (C) and Both AS1 and AS3 vs. LT (D). The analysis was performed using Cytoscape v 3.9.1 and its plug-in Cluego using the set of proteins differentially expressed (p < 0.05) referred in each comparison.