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. 2023 Mar 2;14:1069411. doi: 10.3389/fneur.2023.1069411

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Copyright © 2023 Kivisäkk, Carlyle, Sweeney, Trombetta, LaCasse, El-Mufti, Tuncali, Chibnik, Das, Scherzer, Johnson, Dickerson, Gomez-Isla, Blacker, Oakley, Frosch, Hyman, Aghvanyan, Bathala, Campbell, Sigal, Stengelin and Arnold.

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ROC curves for classification of (A) MCI participants who progressed to a consensus diagnosis of AD dementia during 4 years of follow-up (MCI decline) vs. participants who remained stable during follow-up (MCI stable). (B) AD vs. cognitively normal controls (CN), and (C) AD vs. other neurodegenerative diseases (OND) using pTau181, tTau, NfL, and GFAP alone or all combined in addition to a base model containing age, sex, and APOE status.