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. 2023 Mar 2;14:1120023. doi: 10.3389/fmicb.2023.1120023

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Copyright © 2023 Eriksen, Fuursted, Jensen, Jensen, Nielsen, Christensen, Shewmaker, Rebelo, Aarestrup, Schønning, Slotved and the One Day in Denmark (ODiD) Consortium.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Phylogenetic tree of the concatenated amino acid sequence of PBP1a, PBP2b and PBP2x in Streptococcus pneumoniae with unique PBP-profiles. The tree was constructed using IQ-TREE software with a Blosum62 substitution model. Label contains isolate id, nearest PBP-profile (number of PBP amino acid substitutions), genotypic MIC, phenotypic MIC. Tree is colored by phenotypical susceptibility: Green is susceptible standard dosing regimen blue is susceptible increased exposure, red is resistant. The outlier sequence was constructed from Streptococcus dysgoloctiae AC2713. *indicates category disagreement.