Table 1.
Unique PBP-profiles and PBP1a-, PBP2b- and PBP2x-subtypes in Streptococcus pneumoniae and MLST and genomic serotypes.
| PBP-profile/nearest PPB-profile | Number of isolates | PBP-profile identity % | Substi-tutions | PBP1a | PBP2b | PBP2x | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Nearest subtype | Substi-tutions | Nearest subtype | Substi-tutions | Nearest subtype | Substi-tuitions | MLST (n) | Serotypes (n) | ||||
| Type strain NTCT 7465 PT_0–4-0 | 1 | 100 | 0 | 1a0 | 0 | 2b4 | 0 | 2×0 | 0 | ST615 | 1 |
| PT_0–0-0 | 5 | 100 | 0 | 1a0 | 0 | 2b0 | 0 | 2×0 | 0 | 11,131, 452, 2,964, NA (2) | 12F, 24, 35D (3) |
| PT_0–0-0 | 1 | 99.89 | 1 | 1a0 | 0 | 2b0 | 1 | 2×0 | 0 | 7,179 | 24 |
| PT_0–0-0 | 2 | 99.23 | 7 | 1a86 | 0 | 2b82 | 0 | 2×162 | 0 | 448,1,229 | NT |
| PT_0–0-2 | 1 | 100 | 0 | 1a0 | 0 | 2b0 | 0 | 2×2 | 0 | 4,753 | 10A |
| PT_0–0-28 | 10 | 99.12 | 8 | 1a2 | 0 | 2b0 | 0 | 2×28 | 7 | 162 (9), NA (1) | 24 |
| PT_0–0-3 | 1 | 100 | 0 | 1a0 | 0 | 2b0 | 0 | 2×3 | 0 | NA | 7C |
| PT_0–1-1 | 1 | 97.48 | 23 | 1a0 | 4 | 2b1 | 0 | 2×99 | 7 | 13,224 | 7C |
| PT_0–1-2 | 4 | 99.34 | 6 | 1a2 | 0 | 2b103 | 0 | 2×0 | 0 | 11,100 | 24 |
| PT_1–0-0 | 2 | 100 | 0 | 1a1 | 0 | 2b0 | 0 | 2×0 | 0 | 3,811 | 15A |
| PT_12–0-0 | 1 | 100 | 0 | 1a12 | 0 | 2b0 | 0 | 2×0 | 0 | 1,766 | 31 |
| PT_13–11-33 | 1 | 99.78 | 2 | 1a13 | 1 | 2b11 | 1 | 2×33 | 1 | 271 | 19F |
| PT_13–14-26 | 1 | 100 | 0 | 1a13 | 0 | 2b14 | 0 | 2×26 | 0 | 320 | 19A |
| PT_15–12-18 | 1 | 100 | 0 | 1a15 | 0 | 2b14 | 0 | 2×18 | 0 | 81 | 6A |
| PT-15-14-96 | 1 | 97.81 | 20 | 1a15 | 0 | 2b38 | 0 | 2×43 | 5 | NA | 6A |
| PT_15–16-8 | 1 | 99.78 | 2 | 1a15 | 0 | 2b12 | 0 | 2×8 | 0 | 156 | 11A |
| PT_15–7-8 | 1 | 98.91 | 10 | 1a15 | 0 | 2b49 | 0 | 2×36 | 0 | 166 | 11A |
| PT_15–7-8 | 1 | 98.36 | 15 | 1a15 | 0 | 2b76 | 0 | 2×36 | 4 | 838 | 9 V |
| PT_17–15-22 | 2 | 100 | 0 | 1a17 | 0 | 2b15 | 0 | 2×22 | 0 | 230, NA | 24 |
| PT_17–15-22 | 1 | 98.03 | 18 | 1a17 | 0 | 2b12 | 0 | 2×22 | 0 | 156 | 9 V |
| PT_17–15-22 | 2 | 97.16 | 26 | 1a17 | 0 | 2b15 | 0 | 2×171 | 3 | 4,253 | 24 |
| PT_17–16-47 | 1 | 99.56 | 4 | 1a17 | 0 | 2b39 | 0 | 2×18 | 0 | 276 | 19A |
| PT_18–7-8 | 1 | 97.15 | 26 | 1a10 | 0 | 2b53 | 0 | 2×20 | 0 | NA | 21 |
| PT_2–0-0 | 25 | 100 | 0 | 1a2 | 0 | 2b0 | 0 | 2×0 | 0 | 72 (23), 2,567 (2) | 24 (23), 29 (2) |
| PT_20–18-25 | 1 | 98.58 | 13 | 1a8 | 4 | 2b18 | 0 | 2×25 | 0 | 275 | 15B |
| PT_2–0-2 | 1 | 100 | 0 | 1a2 | 0 | 2b0 | 0 | 2×2 | 0 | 1,262 | 15C |
| PT_2–6-2 / PT_1–6-0 | 1 | 99.78 | 2 | 1a1 | 0 | 2b82 | 0 | 2×2 | 0 | 2,369 | 20 |
| PT_27–11-8 | 1 | 97.81 | 20 | 1a47 | 1 | 2b11 | 0 | 2×8 | 2 | NA | NT |
| PT_34–32-43 | 1 | 100 | 0 | 1a34 | 0 | 2b32 | 0 | 2×43 | 0 | 179 | 19F |
| PT_34–89-147 | 1 | 99.67 | 3 | 1a25 | 0 | 2b7 | 0 | 2×56 | 0 | 8,991 | NT |
| PT_3–6-5 | 7 | 100 | 0 | 1a3 | 0 | 2b6 | 0 | 2×5 | 0 | 53 | 8 |
| PT_4–7-7 | 1 | 100 | 0 | 1a4 | 0 | 2b7 | 0 | 2×7 | 0 | 558 | 35B |
| PT_54–61-92 | 1 | 95.3 | 43 | 1a25 | 15 | 2b15 | 2 | 2×91 | 4 | NA | NT |
| PT_62–0-2 | 3 | 100 | 0 | 1a62 | 0 | 2b0 | 0 | 2×2 | 0 | NA | 3 |
| PT_7–1-1 | 3 | 100 | 0 | 1a7 | 0 | 2b1 | 0 | 2×1 | 0 | 1,349, 13,087 | 1, 23B |
| PT_7–1-30 | 1 | 98.91 | 10 | 1a7 | 0 | 2b1 | 0 | 2×123 | 3 | 3,369 | 35D |
| PT_78–0-0 | 7 | 100 | 0 | 1a78 | 0 | 2b0 | 0 | 2×0 | 0 | 162 | 24 |
| PT_8–67–103 | 1 | 100 | 0 | 1a8 | 0 | 2b67 | 0 | 2×103 | 0 | 135 | 6B |