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. 2023 Mar 2;13:1140765. doi: 10.3389/fcimb.2023.1140765

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Copyright © 2023 Xiao and Xia

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Major DC subsets. In the bone marrow, hematopoietic stem cells (HSCs) differentiate into common myeloid progenitors (CMPs) and common lymphoid progenitors (CLPs). CMPs generate DC-fate restricted progenitors called common DC progenitors (CDPs), which are the common progenitors of pre-cDCs and pre-pDCs. Pre-pDCs are also produced from CLPs. Flt3 binding to the ligand induce the differentiation process. Pre-cDCs are released into the blood to reside in peripheral tissues and lymphoid organs, where they differentiate into cDC1s and cDC2s. pDCs get mature in the bone marrow and then migrate to peripheral lymphoid organs through blood. cDCs and pDCs express different cell surface proteins which distinguish their subsets.