Figure 5.

ForecastECMO salient features by SHAP approach. (A) Analysis of the 20 most relevant features in the ForecastECMO model performance, of the 212 included features, in the total cohort using SHAP approach, with absolute SHAP values on y-axis. The features included supplemental oxygen delivery, use of neuromuscular blockade infusion, hemoglobin measurements, patient position, level of end-expiratory positive pressure ventilation level (CPAP/PEEP), D-dimer measurement, blood glucose level measurement, PLR, antibiotic use, and measurement of minute ventilation as the highest 10 contributing variables. (B) Analysis of the 20 most relevant features in the ForecastECMO model performance, of the 212 included features, in the ECMO cohort using SHAP approach, with SHAP values on y-axis. The 10 highest contributing features included supplemental oxygen delivery, patient position, hemoglobin measurements, use of neuromuscular blockade infusion, use of B agonist agents (usually used for patients with obstructive pulmonary disease), measurement of exhaled tidal volumes on invasive mechanical ventilation, measurement of ETCO2 (a measurement obtained on patients requiring invasive mechanical ventilation), measurement of plateau pressure on invasive mechanical ventilation, measurement of minute ventilation, and use of antibiotics. CPAP: continuous positive airway pressure; BP: blood pressure; ECMO: extracorporeal membrane oxygenation; ETCO2: end tidal carbon dioxide; MAP: mean arterial blood pressure; O₂: oxygen; PEEP: positive end-expiratory pressure; PLR: platelet-to-lymphocyte ratio; Resp: respiratory rate; SHAP: SHapley Additive exPlanations; TV: tidal volume.