Table 6. Kaplan-Meier estimates, unadjusted, & PS-stratified hazard ratios, stratified by clopidogrel or prasugrel use.
Outcome | Prasugrel (n=1,143) | Clopidogrel (n=8,648) | Unadjusted hazard ratio (95% CI) | p-value | PS-stratified hazard ratio* | p-value |
---|---|---|---|---|---|---|
Death or MI | 21 (2.1%) | 223 (3.1%) | 0.67 (0.43-1.05) | 0.082 | 0.66 (0.38-1.13) | 0.13 |
Death | 9 (0.9%) | 108 (1.5%) | 0.59 (0.30-1.17) | 0.133 | 0.57 (0.23-1.44) | 0.236 |
Myocardial infarction | 12 (1.2%) | 104 (1.4%) | 0.83 (0.45-1.50) | 0.533 | 0.85 (0.44-1.67) | 0.64 |
* Propensity score was generated using the following variables: age2, age, gender, BMI (kg/m2), current smoking status, hypertension, hyperlipidaemia, cerebrovascular disease, prior MI, prior CABG, LVEF, acute coronary syndrome, calcification-moderate/severe, chronic total occlusion, and complex PCI. Complex PCI is defined as having one of the following criteria: total stent length ≥60 mm, total number of stents ≥3, number of lesions ≥3, number of vessels ≥3, bifurcation with ≥2 stents, or chronic total occlusion. BMI: body mass index; CABG: coronary artery bypass graft; CI: confidence interval; LVEF: left ventricular ejection fraction; MI: myocardial infarction; PCI: percutaneous coronary intervention; PS: propensity score |