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. 2023 Jan 30;51(5):2151–2176. doi: 10.1093/nar/gkad026

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© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — DNA motif enrichment and footprinting analysis reveal cell state/type specific occupation of key transcription factors. (A, B) chromVAR analysis of DNA motifs recognized by distinct transcription factors enriched in scATAC-seq peaks in a cell state/type specific manner at E14.5 and E17.5. (C, D) Cell state/type-specific footprinting at E14.5 and E17.5 respectively of selected transcription factors as revealed by reduction in Tn5 insertion frequencies around the relevant DNA motifs. Y-axis represents normalized insertion frequencies with the Tn5 incision bias subtracted.