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. 2023 Jan 30;51(5):2151–2176. doi: 10.1093/nar/gkad026

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© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Sequential and combinatorial regulation of RGC-specific genes by Atoh7, Pou4f2 and Isl1. CUT&Tag and E14.5 scATAC-seq genome tracks are displayed for the enhancers associated with six RGC-specific genes, including Eya2, Ablim1, Syt13, Nhlh2, Mstn and Pou6f2. All these genes have RGC specific enhancers, but they are bound differentially by the three transcription factors, representing distinct modes of sequential and combinatorial regulation (see text for detail). Enhancers bound by Atoh7 (blue boxes) tend to be activated early (active in tRPCs already) in the RGC trajectory, whereas those just bound by Pou4f2 and/or Isl1 (red boxes) tend to be activated late. RGC-specific enhancers not bound by any of the three transcription factors (green boxes) likely mediate regulation by additional RGC-specific transcription factors.