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. 2023 Jan 9;51(5):2011–2032. doi: 10.1093/nar/gkac1232

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© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Elongator structural conservation in eukaryotes. (A) Cryo-EM reconstructions of MmElp123–tRNA (upper left), MmElp123 (lower left) and ScElp123–tRNA (upper right) complexes with atomic models in the same orientation. tRNA colored in deep teal. (B) Comparison of the active site of ScElp123–tRNA and MmElp123. Selected, structurally conserved residues in stick representation, with densities shown for iron-sulfur clusters (ScElp123–tRNA/MmElp123), 5′-dA (ScElp123–tRNA) and SAM (MmElp123).