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. 2023 Jan 9;51(5):2011–2032. doi: 10.1093/nar/gkac1232

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© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Graphical Abstract — The Elp123 subcomplex of Elongator captures tRNA substrates and modifies them, whereas the Elp456 assists with the release of the modified tRNAs. Yeast and mouse Elongator are structurally almost identical.