Table 2.
Group | Sub‐group | Criteria | N studies | N participants | N cases | Prevalence (95 CI) | H (95 CI) | I 2 (95 CI) | p‐heterogeneity | p‐dif criteria | p‐diff sub‐groups | p‐Egger test |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Overall | Any criteria | 62 | 86,412 | 3559 | 5.05 [4.27–5.89] | 4.59 [4.25–4.94] | 95.2 [94.5–95.9] | <0.001 | 0.937 | 0.002 | ||
Biochemical criteria only | 0.165 | |||||||||||
OGTT | 13 | 5213 | 217 | 3.31 [1.93–5.02] | 2.95 [2.37–3.67] | 88.5 [82.1–92.6] | <0.001 | 0.390 | ||||
FBG | 9 | 2405 | 229 | 7.89 [4.56–12.00] | 3.29 [2.56–4.23] | 90.7 [84.7–94.4] | <0.001 | 0.401 | ||||
RBG | 2 | 459 | 37 | 6.30 [1.40–19.46] | 4.33 [2.47–7.58] | 94.7 [83.6–98.3] | <0.001 | – | ||||
HbA1c | 7 | 4155 | 287 | 5.06 [1.70–9.99] | 5.82 [4.74–7.14] | 97.0 [95.5–98.0] | <0.001 | 0.632 | ||||
Mixed criteria | 4 | 6750 | 293 | 3.08 [0.00–12.30] | 14.70 [12.57–17.18] | 99.5 [99.4–99.7] | <0.001 | 0.541 | ||||
Self‐report only | 0.274 | |||||||||||
Self‐report | 13 | 14,797 | 470 | 3.48 [2.17–5.07] | 4.63 [3.91–5.48] | 95.3 [93.5–96.7] | <0.001 | 0.264 | ||||
Patient folder | 7 | 5453 | 332 | 5.00 [2.85–7.71] | 3.94 [3.03–5.11] | 93.5 [89.1–96.2] | <0.001 | 0.417 | ||||
Biochemical criteria and/or self‐report | <0.001 | |||||||||||
OGTT | 5 | 1932 | 138 | 6.18 [2.49–11.31] | 3.96 [2.89–5.43] | 93.6 [88.0–96.6] | <0.001 | 0.846 | ||||
FBG | 14 | 10,001 | 702 | 7.16 [5.31–9.26] | 3.49 [2.88–4.22] | 91.8 [87.9–94.4] | <0.001 | 0.683 | ||||
RBG | 1 | 1502 | 7 | 0.47 [0.17–0.89] | − | − | − | − | ||||
HbA1c | 4 | 2991 | 153 | 4.86 [2.40–8.10] | 3.18 [2.11–4.78] | 90.1 [77.6–95.6] | <0.001 | 0.998 | ||||
Mixed criteria | 13 | 55,145 | 1740 | 4.15 [3.05–5.41] | 4.52 [3.81–5.36] | 95.1 [93.1–96.5] | <0.001 | 0.215 | ||||
Age | ||||||||||||
Median age, 41 years old | ≥39 years | Any criteria | 25 | 18,378 | 1053 | 5.96 [4.51–7.60] | 4.20 [3.70–4.77] | 94.3 [92.7–95.6] | <0.001 | 0.002 | 0.129 | 0.448 |
Biochemical criteria only | 0.375 | |||||||||||
OGTT | 2 | 1440 | 125 | 11.99 [3.71–24.02] | 3.74 [2.05–6.83] | 92.8 [76.1–97.9] | <0.001 | 0.016 | 0.523 | |||
FBG | 6 | 1580 | 131 | 7.67 [3.70–12.87] | 3.30 [2.41–4.52] | 90.8 [82.8–95.1] | <0.001 | 0.891 | 0.986 | |||
RBG | 1 | 270 | 33 | 12.22 [8.56–16.42] | − | − | − | − | ||||
HbA1c | 5 | 2461 | 254 | 6.91 [2.75–12.71] | 4.40 [3.27–5.92] | 94.8 [90.7–97.1] | <0.001 | 0.019 | 0.176 | |||
Mixed criteria | 3 | 3771 | 280 | 4.48 [0.00–20.26] | 15.84 [13.22–18.98] | 99.6 [99.4–99.7] | <0.001 | − | 0.915 | |||
Self‐report | 0.091 | |||||||||||
Self‐report | 7 | 6561 | 209 | 3.78 [2.39–5.47] | 2.99 [2.21–4.06] | 88.8 [79.5–93.9] | <0.001 | 0.686 | 0.180 | |||
Patient folder | 2 | 1535 | 37 | 2.40 [1.64–3.28] | 1.04 [–] | 8.3 [–] | 0.296 | 0.774 | − | |||
Biochemical criteria and/or self‐report | 0.346 | |||||||||||
OGTT | 2 | 546 | 54 | 6.66 [0.00–30.20] | 7.54 [5.01–11.36] | 98.2 [96.0–99.2] | <0.001 | 0.919 | ||||
FBG | 7 | 7057 | 487 | 6.89 [3.84–10.72] | 4.74 [3.76–5.99] | 95.6 [92.9–97.2] | <0.001 | 0.802 | 0.997 | |||
RBG | 0 | − | − | − | − | − | − | |||||
HbA1c | 3 | 2707 | 129 | 3.96 [1.52–7.46] | 3.43 [2.14–5.50] | 91.5 [78.2–96.7] | <0.001 | 0.050 | 0.736 | |||
Mixed criteria | 8 | 4359 | 165 | 3.89 [2.88–5.04] | 1.71 [1.17–2.49] | 65.7 [27.1–83.9] | 0.004 | 0.328 | 0.296 | |||
<39 years | Any criteria | 24 | 55,455 | 1868 | 4.50 [3.45–5.68] | 3.99 [3.49–4.56] | 93.7 [91.8–95.2] | <0.001 | 0.131 | 0.002 | ||
Biochemical criteria only | 0.095 | |||||||||||
OGTT | 7 | 2142 | 54 | 2.33 [1.60–3.18] | 1.13 [1.00–1.68] | 21.2 [0.0–64.5] | 0.267 | 0.883 | ||||
FBG | 3 | 825 | 98 | 8.28 [2.44–16.99] | 3.42 [2.13–5.48] | 91.4 [78.0–96.7] | <0.001 | 0.070 | ||||
RBG | 0 | − | − | − | − | − | − | |||||
HbA1c | 1 | 1207 | 26 | 2.15 [1.40–3.06] | − | − | − | |||||
Mixed criteria | 0 | − | − | − | − | − | − | |||||
Self‐report | 0.148 | |||||||||||
Self‐report | 3 | 2147 | 75 | 3.48 [2.74–4.30] | 1.00 [1.00–3.10] | 0.0 [0.0–89.6] | 0.699 | 0.327 | ||||
Patient folder | 1 | 382 | 8 | 2.09 [0.86–3.81] | − | − | − | |||||
Biochemical criteria and/or self‐report | <0.001 | |||||||||||
OGTT | 3 | 1386 | 84 | 5.90 [4.18–7.89] | 1.41 [1.00–2.62] | 49.7 [0.0–85.4] | 0.136 | 0.815 | ||||
FBG | 6 | 2482 | 178 | 7.42 [5.41–9.72] | 2.05 [1.37–3.07] | 76.2 [46.6–89.4] | 0.001 | 0.034 | ||||
RBG | 1 | 1502 | 7 | 0.47 [0.17–0.89] | − | − | − | |||||
HbA1c | 1 | 284 | 24 | 8.45 [5.47–11.99] | − | − | − | |||||
Mixed criteria | 5 | 47,131 | 1490 | 5.14 [3.32–7.32] | 4.88 [3.70–6.45] | 95.8 [92.7–97.6] | <0.001 | 0.165 | ||||
Gender | ||||||||||||
Men | Any criteria | 22 | 8142 | 423 | 4.85 [3.59–6.29] | 2.67 [2.24–3.18] | 86.0 [80.0–90.1] | <0.001 | 0.223 | 0.524 | 0.994 | |
Biochemical criteria only | <0.001 | |||||||||||
OGTT | 2 | 540 | 8 | 1.43 [0.53–2.68] | 1.00 | 00.0 | 0.923 | 0.278 | ||||
FBG | 2 | 170 | 15 | 8.54 [4.64–13.38] | 1.00 | 00.0 | 0.325 | 0.249 | ||||
RBG | 0 | − | − | − | − | − | − | |||||
HbA1c | 2 | 581 | 13 | 1.85 [0.79–3.25] | 1.00 | 00.0 | 0.737 | 0.625 | ||||
Mixed criteria | 0 | − | − | − | − | − | − | |||||
Self‐report | 0.798 | |||||||||||
Self‐report | 6 | 2428 | 92 | 3.36 [1.89–5.22] | 2.20 [1.49–3.25] | 79.3 [54.8–90.5] | <0.001 | 0.990 | 0.647 | |||
Patient folder | 3 | 567 | 19 | 3.71 [0.95–7.95] | 2.03 [1.12–3.69] | 75.8 [20.3–92.7] | 0.016 | 0.589 | 0.308 | |||
Biochemical criteria and/or self‐report | 0.115 | |||||||||||
OGTT | 1 | 157 | 10 | 6.37 [3.01–10.80] | − | − | − | 0.889 | ||||
FBG | 5 | 1873 | 164 | 8.05 [4.95–11.81] | 2.30 [1.51–3.51] | 81.1 [56.1–91.9] | <0.001 | 0.119 | 0.763 | |||
RBG | 0 | − | − | − | − | − | − | |||||
HbA1c | 0 | − | − | − | − | − | − | |||||
Mixed criteria | 6 | 3104 | 141 | 4.28 [2.59–6.35] | 2.45 [1.69–3.55] | 83.4 [65.2–92.1] | <0.001 | 0.958 | 0.963 | |||
Women | Any criteria | 22 | 17,846 | 827 | 4.47 [3.66–5.36] | 2.60 [2.17–3.11] | 85.2 [78.8–89.7] | <0.001 | 0.324 | 0.946 | ||
Biochemical criteria only | 0.009 | |||||||||||
OGTT | 2 | 1298 | 32 | 2.48 [1.40–3.85] | 1.41 [–] | 49.8 [–] | 0.158 | – | ||||
FBG | 2 | 419 | 26 | 6.14 [3.99–8.68] | 1.00 [–] | 0.0 [–] | 0.493 | – | ||||
RBG | 0 | − | − | − | − | − | − | |||||
HbA1c | 2 | 801 | 20 | 2.85 [0.84–5.87] | 1.61 [1.00–3.35] | 61.5 [0.0–91.1] | 0.107 | – | ||||
Mixed criteria | 0 | − | − | − | − | − | − | |||||
Self‐report | 0.636 | |||||||||||
Self‐report | 6 | 6370 | 262 | 3.46 [2.16–5.05] | 3.07 [2.21–4.26] | 89.4 [79.5–94.5] | <0.001 | 0.179 | ||||
Patient folder | 3 | 1178 | 32 | 2.80 [1.25–4.88] | 1.71 [1.00–3.18] | 65.6 [0.0–90.1] | 0.054 | 0.663 | ||||
Biochemical criteria and/or self‐report | 0.297 | |||||||||||
OGTT | 1 | 591 | 37 | 6.26 [4.44–8.37] | ||||||||
FBG | 5 | 4673 | 280 | 5.82 [4.41–7.40] | 1.70 [1.05–2.75] | 65.3 [9.1–86.7] | 0.021 | 0.957 | ||||
RBG | 0 | − | − | − | − | − | − | |||||
HbA1c | 0 | − | − | − | − | − | − | |||||
Mixed criteria | 6 | 5206 | 203 | 4.28 [2.66–6.24] | 3.13 [2.26–4.33] | 89.8 [80.5–94.7] | <0.001 | 0.096 | ||||
BMI | ||||||||||||
Median BMI, 23 kg/m2 | BMI≥23 kg/m2 | Any criteria | 13 | 5913 | 408 | 7.06 [4.66–9.89] | 3.72 [3.07–4.50] | 92.8 [89.4–95.1] | <0.001 | 0.002 | 0.106 | 0.433 |
Biochemical criteria only | 0.095 | |||||||||||
OGTT | 5 | 1718 | 49 | 2.71 [1.97–3.57] | 1.00 [1.00–2.19] | 0.0 [0.0–79.2] | 0.532 | 0.175 | 0.441 | |||
FBG | 2 | 272 | 39 | 14.93 [1.49–37.95] | 4.36 [2.49–7.62] | 94.7 [83.9–98.3] | <0.001 | 0.314 | – | |||
HbA1c | 1 | 1207 | 26 | 2.15 [1.40–3.06] | − | − | − | 0.011 | – | |||
Self‐report | 0.685 | |||||||||||
Self‐report | 2 | 1206 | 41 | 3.38 [2.42–4.49] | 1.00 | 00.0 | 0.418 | 0.284 | ||||
Patient folder | 1 | 502 | 15 | 2.99 [1.66–4.68] | − | − | − | – | ||||
Biochemical criteria and/or self‐report | 0.418 | |||||||||||
OGTT | 2 | 1054 | 99 | 10.97 [2.78–23.55] | 5.07 [3.02–8.49] | 96.1 [89.1–98.6] | <0.001 | 0.303 | – | |||
FBG | 3 | 1265 | 112 | 8.02 [1.84–17.86] | 5.34 [3.70–7.71] | 96.5 [92.7–98.3] | <0.001 | 0.773 | 0.938 | |||
HbA1c | 1 | 502 | 35 | 6.97 [4.90–9.38] | − | − | − | 0.439 | ||||
Mixed criteria | 2 | 2276 | 128 | 5.60 [4.69–6.59] | 1.00 [–] | 00.0 [–] | 0.909 | 0.430 | ||||
BMI<23 kg/m2 | Any criteria | 14 | 13,511 | 614 | 4.51 [2.81–6.57] | 4.91 [4.20–5.73] | 95.8 [94.3–97.0] | <0.001 | 0.606 | 0.832 | ||
Biochemical criteria only | <0.001 | |||||||||||
OGTT | 1 | 273 | 4 | 1.47 [0.31–3.31] | − | − | − | |||||
FBG | 2 | 543 | 36 | 6.54 [4.57–8.81] | − | − | − | |||||
HbA1c | 1 | 118 | 8 | 6.78 [2.84–12.13] | 1.00 | 00.0 | 0.498 | |||||
Mixed criteria | 1 | 1316 | 2 | 0.15 [0.00–0.46] | − | − | − | |||||
Self‐report | − | |||||||||||
Self‐report | 3 | 1678 | 61 | 6.43 [1.46–14.36] | 3.98 [2.57–6.14] | 93.7 [84.9–97.4] | <0.001 | |||||
Biochemical criteria and/or self‐report | <0.001 | |||||||||||
OGTT | 2 | 638 | 37 | 5.61 [2.60–9.64] | 1.95 [1.00–4.11] | 73.7 [0.0–94.1] | 0.051 | |||||
FBG | 5 | 5516 | 397 | 7.34 [3.96–11.62] | 3.76 [2.72–5.21] | 92.9 [86.5–96.3] | <0.001 | 0.978 | ||||
RBG | 1 | 1502 | 7 | 0.47 [0.17–0.89] | − | − | − | |||||
HbA1c | 1 | 284 | 24 | 8.45 [5.47–11.99] | − | − | − | |||||
Mixed criteria | 5 | 5577 | 190 | 4.53 [2.41–7.26] | 4.02 [2.94–5.50] | 93.8 [88.5–96.7] | <0.001 | 0.083 | ||||
Area | ||||||||||||
Combined | Any criteria | 21 | 13,590 | 765 | 5.99 [4.68–7.45] | 3.23 [2.75–3.80] | 90.4 [86.7–93.1] | <0.001 | <0.001 | 0.308 | 0.163 | |
Biochemical criteria only | 0.126 | |||||||||||
OGTT | 4 | 1612 | 47 | 2.81 [2.03–3.70] | 1.00 [1.00–2.56] | 0.0 [0.0–84.7] | 0.395 | 0.621 | 0.162 | |||
FBG | 3 | 418 | 13 | 3.00 [1.02–5.82] | 1.39 [1.00–2.58] | 48.4 [0.0–85.0] | 0.143 | 0.002 | 0.103 | |||
RBG | 0 | − | − | − | − | − | − | |||||
HbA1c | 1 | 118 | 8 | 6.78 [2.84–12.13] | − | − | − | 0.360 | ||||
Mixed criteria | 0 | − | − | − | − | − | − | 0.818 | ||||
Self‐report | 0.950 | |||||||||||
Self‐report | 7 | 8212 | 369 | 4.36 [3.13–5.78] | 2.69 [1.95–3.72] | 86.2 [73.7–92.8] | <0.001 | <0.001 | 0.934 | |||
Patient folder | 2 | 832 | 36 | 4.46 [1.72–8.35] | 2.29 [1.11–4.74] | 81.0 [19.0–95.5] | 0.021 | 0.757 | ||||
Biochemical criteria and/or self‐report | 0.008 | |||||||||||
OGTT | 3 | 1360 | 111 | 8.29 [2.93–15.98] | 4.21 [2.76–6.41] | 94.4 [86.9–97.6] | <0.001 | 0.342 | 0.757 | |||
FBG | 7 | 2824 | 248 | 9.48 [6.43–13.04] | 2.97 [2.18–4.03] | 88.6 [79.0–93.8] | <0.001 | 0.194 | 0.098 | |||
HbA1c | 2 | 2328 | 125 | 5.72 [3.88–7.87] | 1.76 [1.00–3.71] | 67.9 [0.0–92.8] | 0.077 | 0.679 | ||||
Mixed criteria | 2 | 1552 | 69 | 4.43 [3.46–5.52] | 1.00 | 00.0 | 0.394 | <0.001 | ||||
Urban | Any criteria | 37 | 68,894 | 2652 | 4.80 [3.81–5.88] | 4.88 [4.44–5.36] | 95.8 [94.9–96.5] | <0.001 | 0.217 | 0.033 | ||
Biochemical criteria only | 0.001 | |||||||||||
OGTT | 9 | 3601 | 170 | 3.38 [1.48–5.97] | 3.47 [2.72–4.42] | 91.7 [86.5–94.9] | <0.001 | 0.324 | ||||
FBG | 6 | 1987 | 216 | 10.70 [6.56–15.68] | 3.21 [2.33–4.42] | 90.3 [81.6–94.9] | <0.001 | 0.861 | ||||
RBG | 1 | 270 | 33 | 12.22 [8.56–16.42] | − | − | − | |||||
HbA1c | 5 | 3537 | 260 | 5.04 [1.01–11.78] | 7.03 [5.63–8.78] | 98.0 [96.8–98.7] | <0.001 | 0.644 | ||||
Mixed criteria | 3 | 5584 | 272 | 3.58 [0.00–18.00] | 17.99 [15.24–21.22] | 99.7 [99.6–99.8] | <0.001 | 0.624 | ||||
Self‐report | 0.178 | |||||||||||
Self‐report | 5 | 5419 | 86 | 2.64 [0.90–5.21] | 4.33 [3.21–5.85] | 94.7 [90.3–97.1] | <0.001 | 0.019 | ||||
Patient folder | 5 | 4621 | 296 | 5.21 [2.51–8.78] | 4.56 [3.41–6.09] | 95.2 [91.4–97.3] | <0.001 | 0.542 | ||||
Biochemical criteria and/or self‐report | 0.697 | |||||||||||
OGTT | 2 | 572 | 27 | 3.47 [0.00–12.74] | 4.23 [2.40–7.45] | 94.4 [82.6–98.2] | <0.001 | |||||
FBG | 6 | 6074 | 409 | 5.53 [3.00–8.74] | 3.75 [2.80–5.02] | 92.9 [87.2–96.0] | <0.001 | 0.508 | ||||
HbA1c | 2 | 663 | 28 | 3.91 [0.00–14.17] | 4.81 [2.83–8.18] | 95.7 [87.5–98.5] | <0.001 | |||||
Mixed criteria | 10 | 52,459 | 1585 | 3.76 [2.62–5.10] | 4.53 [3.72–5.51] | 95.1 [92.8–96.7] | <0.001 | 0.526 | ||||
Rural | Any criteria | 5 | 3928 | 142 | 3.83 [0.94–8.40] | 5.59 [4.33–7.23] | 96.8 [94.7–98.1] | <0.001 | 0.382 | 0.621 | ||
Biochemical criteria only | 0.065 | |||||||||||
RBG | 1 | 189 | 4 | 2.12 [0.45–4.76] | − | − | − | |||||
HbA1c | 1 | 500 | 19 | 3.80 [2.28–5.67] | − | − | − | |||||
Mixed criteria | 1 | 1166 | 21 | 1.80 [1.11–2.65] | − | − | − | |||||
Self‐report | − | − | − | |||||||||
Self‐report | 23 | 1166 | 15 | 1.29 [0.71–2.02] | − | − | − | |||||
Biochemical criteria and/or self‐report | <0.001 | |||||||||||
FBG | 2 | 1103 | 45 | 5.98 [1.02–14.28] | 2.56 [1.27–5.18] | 84.8 [37.9–96.3] | 0.010 | |||||
RBG | 1 | 1502 | 7 | 0.47 [0.17–0.89] | − | − | − | |||||
Mixed criteria | 1 | 1134 | 86 | 7.58 [6.11–9.20] | − | − | − | |||||
Study setting | ||||||||||||
Clinic‐based | Any criteria | 54 | 77,474 | 3133 | 5.21 [4.32–6.19] | 4.78 [4.41–5.17] | 95.6 [94.9–96.3] | <0.001 | 0.970 | 0.193 | 0.003 | |
Biochemical criteria only | <0.001 | |||||||||||
OGTT | 12 | 4726 | 207 | 3.45 [1.94–5.33] | 3.00 [2.39–3.76] | 88.9 [82.5–92.9] | <0.001 | 0.165 | 0.387 | |||
FBG | 9 | 2405 | 229 | 7.89 [4.56–12.00] | 3.29 [2.56–4.23] | 90.7 [84.7–94.4] | <0.001 | − | 0.400 | |||
RBG | 1 | 270 | 33 | 12.22 [8.56–16.42] | <0.001 | |||||||
HbA1c | 6 | 3668 | 280 | 5.88 [1.97–11.61] | 5.84 [4.67–7.30] | 97.1 [95.4–98.1] – | <0.001 | 0.028 | 0.748 | |||
Mixed criteria | 4 | 6750 | 293 | 3.08 [0.00–12.30] | 14.70 [12.57–17.18] | 99.5 [99.4–99.7] | <0.001 | − | 0.541 | |||
Self‐report | 0.164 | |||||||||||
Self‐report | 8 | 7669 | 144 | 2.93 [1.47–4.85] | 4.06 [3.20–5.14] | 93.9 [90.2–96.2] | <0.001 | 0.234 | 0.001 | |||
Patient folder | 7 | 5453 | 332 | 5.00 [2.85–7.71] | 3.94 [3.03–5.11] | 93.5 [89.1–96.2] | <0.001 | − | 0.417 | |||
Biochemical criteria and/or self‐report | <0.001 | |||||||||||
OGTT | 5 | 1932 | 138 | 6.18 [2.49–11.31] | 3.96 [2.89–5.43] | 93.6 [88.0–96.6] | <0.001 | − | 0.846 | |||
FBG | 14 | 10,001 | 702 | 7.16 [5.31–9.26] | 3.49 [2.88–4.22] | 91.8 [87.9–94.4] | <0.001 | − | 0.683 | |||
RBG | 1 | 1502 | 7 | 0.47 [0.17–0.89] | − | − | − | − | ||||
HbA1c | 4 | 2991 | 153 | 4.86 [2.40–8.10] | 3.18 [2.11–4.78] | 90.1 [77.6–95.6] | <0.001 | − | 0.998 | |||
Mixed criteria | 12 | 54,011 | 1654 | 3.88 [2.84–5.06] | 4.21 [3.50–5.07] | 94.4 [91.8–96.1] | <0.001 | <0.001 | 0.347 | |||
Community‐based | Any criteria | 8 | 8938 | 426 | 4.18 [2.98–5.57] | 2.83 [2.12–3.79] | 87.6 [77.7–93.1] | <0.001 | 0.441 | |||
Biochemical criteria only | 0.693 | |||||||||||
OGTT | 1 | 487 | 10 | 2.05 [0.95–3.53] | − | − | − | |||||
RBG | 1 | 189 | 4 | 2.12 [0.45–4.76] | − | − | − | |||||
HbA1c | 1 | 487 | 7 | 1.44 [0.54–2.72] | − | − | − | |||||
Self‐report | ||||||||||||
Self‐report | 5 | 7128 | 326 | 4.32 [3.10–5.73] | 2.54 [1.70–3.79] | 84.5 [65.2–93.1] | <0.001 | 0.761 | ||||
Biochemical criteria and/or self‐report | ||||||||||||
Mixed criteria | 1 | 1134 | 86 | 7.58 [6.11–9.20] | – | – | – | |||||
Publication year | ||||||||||||
Median publication year 2018 | 2018 or later | Any criteria | 34 | 28,020 | 1547 | 5.78 [4.42–7.29] | 5.00 [4.54–5.51] | 96.0 [95.2–96.7] | <0.001 | 0.559 | 0.063 | 0.138 |
Biochemical criteria only | 0.722 | |||||||||||
OGTT | 3 | 2449 | 127 | 3.90 [1.21–7.99] | 4.19 [2.75–6.40] | 94.3 [86.8–97.6] | <0.001 | 0.740 | 0.120 | |||
FBG | 6 | 1863 | 177 | 6.72 [3.25–11.27] | 3.33 [2.43–4.55] | 91.0 [83.1–95.2] | <0.001 | 0.601 | 0.067 | |||
HbA1c | 5 | 3480 | 261 | 5.56 [1.21–12.65] | 7.01 [5.61–8.75] | 98.0 [96.8–98.7] | <0.001 | 0.548 | 0.765 | |||
Mixed criteria | 3 | 5584 | 272 | 3.58 [0.00–18.00] | 17.99 [15.24–21.22] | 99.7 [99.6–99.8] | <0.001 | 0.818 | 0.624 | |||
Self‐report | 0.359 | |||||||||||
Self‐report | 10 | 12,925 | 427 | 3.64 [2.08–560] | 5.13 [4.27–6.15] | 96.2 [94.5–97.4] | <0.001 | 0.686 | 0.333 | |||
Patient folder | 5 | 2620 | 166 | 5.16 [2.60–849] | 3.21 [2.25–4.58] | 90.3 [80.3–95.2] | <0.001 | 0.858 | 0.349 | |||
Biochemical criteria and/or self‐report | <0.001 | |||||||||||
OGTT | 5 | 1932 | 138 | 6.18 [2.49–11.31] | 3.96 [2.89–5.43] | 93.6 [88.0–96.6] | <0.001 | − | 0.846 | |||
FBG | 8 | 6608 | 562 | 10.21 [7.99–12.67] | 2.45 [1.79–3.36] | 83.3 [68.7–91.1] | <0.001 | <0.001 | 0.029 | |||
RBG | 1 | 1502 | 7 | 0.47 [0.17–0.89] | – | – | – | |||||
HbA1c | 4 | 2991 | 153 | 4.86 [2.40–8.10] | 3.18 [2.11–4.78] | 90.1 [77.6–95.6] | <0.001 | 0.998 | ||||
Mixed criteria | 8 | 6718 | 195 | 4.15 [2.05–6.92] | 4.60 [3.69–5.73] | 94.4 [91.6–96.3] | <0.001 | 0.737 | 0.007 | |||
Before 2018 | Any criteria | 28 | 58,392 | 2012 | 4.18 [3.33–5.12] | 3.53 [3.10–4.03] | 92.0 [89.6–93.9] | <0.001 | 0.871 | 0.055 | ||
Biochemical criteria only | 0.012 | |||||||||||
OGTT | 10 | 2764 | 90 | 3.12 [1.61–5.06] | 2.49 [1.89–3.29] | 83.9 [72.0–90.8] | <0.001 | 0.361 | ||||
FBG | 3 | 542 | 52 | 10.86 [2.49–23.83] | 3.94 [2.55–6.10] | 93.6 [84.6–97.3] | <0.001 | 0.269 | ||||
RBG | 2 | 459 | 37 | 6.30 [0.14–19.46] | 4.33 [2.47–7.58] | 94.7 [83.6–98.3] | <0.001 | |||||
HbA1c | 2 | 675 | 26 | 3.81 [2.46–5.42] | 1.00 | 00.0 | 0.833 | |||||
Mixed criteria | 1 | 1166 | 21 | 1.80 [0.11–2.65] | – | – | – | |||||
Self‐report | 0.597 | |||||||||||
Self‐report | 3 | 1872 | 43 | 2.96 [0.92–6.04] | 2.91 [1.75–4.86] | 88.2 [67.2–95.8] | <0.001 | 0.068 | ||||
Patient folder | 2 | 2833 | 166 | 4.64 [0.63–12.01] | 7.13 [4.67–10.89] | 98.0 [95.4–99.2] | <0.001 | |||||
Biochemical criteria and/or self‐report | 0.566 | |||||||||||
FBG | 6 | 3393 | 140 | 3.90 [2.28–5.91] | 2.70 [1.90–3.84] | 86.3 [72.4–93.2] | <0.001 | 0.921 | ||||
Mixed criteria | 5 | 48,427 | 1545 | 4.28 [2.88–5.95] | 4.64 [3.48–6.18] | 94.8 [91.4–96.8] | <0.001 | 0.053 | ||||
CD4 count level | ||||||||||||
Median CD4 count = 358 cells/μl | CD4 count≥358 cells/μl | Any criteria | 14 | 9805 | 588 | 5.55 [3.28–8.36] | 4.93 [4.22–5.75] | 95.9 [94.4–97.0] | <0.001 | 0.002 | 0.298 | 0.955 |
Biochemical criteria only | <0.001 | |||||||||||
OGTT | 2 | 780 | 25 | 3.55 [1.34–6.66] | 1.46 [1.00–2.93] | 53.0 [0.0–88.3] | 0.144 | 0.303 | ||||
FBG | 4 | 843 | 52 | 6.05 [4.50–7.80] | 1.00 [1.00–2.56] | 0.0 [0.0–84.7] | 0.520 | 0.718 | 0.262 | |||
HbA1c | 2 | 293 | 15 | 5.05 [2.65–8.11] | 1.05 | 9.9 | 0.292 | 0.111 | ||||
Mixed criteria | 1 | 1166 | 21 | 1.80 [1.11–2.65] | − | − | − | <0.001 | ||||
Self‐report | 0.309 | |||||||||||
Self‐report | 4 | 2490 | 73 | 4.14 [1.55–7.83] | 3.61 [2.47–5.29] | 92.3 [83.6–96.4] | <0.001 | 0.164 | 0.087 | |||
Patient folder | 2 | 884 | 23 | 2.58 [1.62–3.75] | 1.00 | 00.0 | 0.426 | 0.464 | – | |||
Biochemical criteria and/or self‐report | <0.001 | |||||||||||
OGTT | 2 | 988 | 49 | 3.09 [0.01–10.41] | 4.13 [2.33–7.33] | 94.1 [81.5–98.1] | <0.001 | 0.218 | ||||
FBG | 5 | 5642 | 446 | 9.47 [5.31–14.64] | 4.28 [3.17–5.79] | 94.5 [90.0–97.0] | <0.001 | 0.506 | 0.560 | |||
RBG | 1 | 1502 | 7 | 0.47 [0.17–0.89] | − | − | − | – | ||||
HbA1c | 1 | 502 | 35 | 6.97 [4.90–9.38] | − | − | − | 0.439 | ||||
Mixed criteria | 2 | 1058 | 56 | 5.29 [4.01–6.73] | 1.00 | 00.0 | 0.704 | |||||
CD4 count<358 cells/μl | Any criteria | 13 | 9974 | 374 | 4.06 [2.72–5.65] | 3.42 [2.80–4.19] | 91.5 [87.2–94.3] | <0.001 | 0.027 | 0.289 | ||
Biochemical criteria only | <0.001 | |||||||||||
OGTT | 4 | 1211 | 28 | 2.22 [1.43–3.17] | 1.00 [1.00–2.56] | 0.0 [0.0–84.7] | 0.641 | 0.690 | ||||
FBG | 2 | 272 | 30 | 10.13 [0.00–44.88] | 6.69 [4.31–10.39] | 97.8 [94.6–99.1] | <0.001 | |||||
HbA1c | 2 | 1707 | 45 | 2.82 [1.42–4.67] | 1.88 [1.00–3.96] | 71.6 [0.0–93.6] | 0.060 | |||||
Mixed criteria | 1 | 1316 | 2 | 0.15 [0.00–0.46] | − | − | − | |||||
Self‐report | − | − | − | 0.916 | ||||||||
Self‐report | 1 | 1316 | 29 | 2.20 [1.47–3.07] | − | − | − | |||||
Patient folder | 1 | 1033 | 22 | 2.13 [1.33–3.11] | − | − | − | |||||
Biochemical criteria and/or self‐report | − | − | − | 0.229 | ||||||||
OGTT | 1 | 332 | 25 | 7.53 [4.91–10.64] | − | − | − | |||||
FBG | 2 | 740 | 58 | 7.78 [5.78–10.05] | 1.09 | 16.5 | 0.273 | |||||
HbA1c | 1 | 284 | 24 | 8.45 [5.47–11.99] | − | − | − | |||||
Mixed criteria | 5 | 7050 | 277 | 4.78 [2.65–7.47] | 4.58 [3.43–6.12] | 95.2 [91.5–97.3] | <0.001 | 0.167 | ||||
ART use | ||||||||||||
Combined | Any criteria | 18 | 18,294 | 926 | 5.38 [3.82–7.18] | 4.92 [4.29–5.64] | 95.9 [94.6–96.9] | <0.001 | 0.928 | 0.827 | 0.142 | |
Biochemical criteria only | <0.001 | |||||||||||
OGTT | 2 | 967 | 23 | 2.18 [1.02–3.75] | 1.36 | 46.3 | 0.172 | 0.404 | ||||
FBG | 2 | 1020 | 134 | 12.97 [8.38–18.37] | 2.42 [1.18–4.95] | 82.9 [28.8–95.9] | 0.015 | 0.006 | ||||
RBG | 1 | 189 | 4 | 2.12 [0.45–4.76] | <0.001 | |||||||
HbA1c | 1 | 500 | 19 | 3.80 [2.28–5.67] | − | − | − | 0.644 | ||||
Mixed criteria | 1 | 2979 | 13 | 0.44 [0.23–0.71] | − | − | − | <0.001 | ||||
Self‐report | 0.001 | |||||||||||
Self‐report | 9 | 11,739 | 396 | 3.43 [1.84–5.48] | 5.21 [4.31–6.31] | 96.3 [94.6–97.5] | <0.001 | 0.918 | 0.484 | |||
Patient folder | 2 | 2130 | 165 | 7.70 [6.60–8.88] | 1.00 | 00.0 | 0.324 | 0.005 | ||||
Biochemical criteria and/or self‐report | ||||||||||||
OGTT | 1 | 748 | 47 | 6.28 [4.65–8.14] | − | − | − | 0.956 | ||||
FBG | 3 | 1719 | 96 | 6.60 [2.87–11.67] | 3.43 [2.14–5.50] | 91.5 [78.2–96.7] | <0.001 | 0.847 | 0.196 | |||
Mixed criteria | 3 | 5065 | 150 | 3.61 [0.50–9.31] | 7.95 [5.97–10.59] | 98.4 [97.2–99.1] | <0.001 | 0.304 | 0.283 | |||
No ART | Any criteria | 17 | 48,048 | 1633 | 5.16 [3.56–7.01] | 4.05 [3.46–4.74] | 93.9 [91.6–95.6] | <0.001 | 0.927 | 0.040 | ||
Biochemical criteria only | <0.001 | |||||||||||
OGTT | 5 | 2220 | 119 | 3.22 [0.96–6.67] | 3.60 [2.58–5.02] | 92.3 [85.0–96.0] | <0.001 | 0.015 | ||||
FBG | 2 | 244 | 33 | 12.67 [0.00–41.12] | 5.21 [3.14–8.66] | 96.3 [89.8–98.7] | <0.001 | |||||
HbA1c | 3 | 2476 | 200 | 5.53 [0.04–18.54] | 9.93 [7.75–12.73] | 99.0 [98.3–99.4] | <0.001 | 0.901 | ||||
Mixed criteria | 1 | 954 | 223 | 23.38 [20.74–26.12] | − | − | − | |||||
Self‐report | − | − | − | |||||||||
Self‐report | 0 | − | − | − | − | − | − | |||||
Patient folder | 1 | 244 | 8 | 3.28 [1.65–6.42] | − | − | − | |||||
Biochemical criteria and/or self‐report | <0.001 | |||||||||||
OGTT | 2 | 638 | 37 | 5.61 [2.60–9.64] | 1.95 [1.00–4.11] | 73.7 [0.0–94.1] | 0.051 | |||||
FBG | 5 | 1112 | 98 | 8.07 [4.09–13.17] | 2.65 [1.79–3.93] | 85.8 [68.8–93.5] | <0.001 | 0.964 | ||||
RBG | 1 | 285 | 1 | 0.35 [0.00–1.50] | − | − | − | 0.960 | ||||
HbA1c | 2 | 528 | 40 | 7.55 [5.42–9.98] | 1.00 | 00.0 | 0.421 | 0.100 | ||||
Mixed criteria | 4 | 44,213 | 1411 | 6.03 [3.12–9.77] | 5.25 [3.87–7.13] | 96.4 [93.3–98.0] | <0.001 | 0.138 | ||||
ART use | Any criteria | 35 | 20,070 | 1000 | 4.72 [3.54–6.05] | 3.99 [3.57–4.45] | 93.7 [92.2–94.9] | <0.001 | 0.761 | 0.652 | ||
Biochemical criteria only | 0.001 | |||||||||||
OGTT | 8 | 2026 | 75 | 3.79 [1.78–6.45] | 2.63 [1.94–3.56] | 85.5 [73.4–92.1] | <0.001 | 0.221 | ||||
FBG | 5 | 1141 | 62 | 4.83 [2.83–7.30] | 1.68 [1.04–2.72] | 64.5 [6.7–86.5] | 0.023 | 0.415 | ||||
RBG | 1 | 270 | 33 | 12.22 [8.56–16.42] | − | − | − | |||||
HbA1c | 5 | 1179 | 68 | 5.03 [2.79–7.84] | 1.91 [1.20–3.02] | 72.5 [30.9–89.0] | 0.005 | 0.385 | ||||
Mixed criteria | 3 | 2817 | 57 | 2.67 [0.06–8.50] | 6.67 [4.84–9.19] | 97.8 [95.7–98.8] | <0.001 | 0.265 | ||||
Self‐report | ||||||||||||
Self‐report | 4 | 3058 | 74 | 3.52 [1.43–6.45] | 3.40 [2.29–5.03] | 91.3 [80.9–96.1] | <0.001 | 0.089 | ||||
Patient folder | 5 | 3079 | 159 | 4.17 [1.56–7.90] | 4.13 [3.04–5.62] | 94.1 [89.2–96.8] | <0.001 | 0.694 | ||||
Biochemical criteria and/or self‐report | <0.001 | |||||||||||
OGTT | 2 | 546 | 54 | 6.66 [0.00–30.20] | 7.54 [5.01–11.36] | 98.2 [96.0–99.2] | <0.001 | |||||
FBG | 10 | 7170 | 508 | 6.90 [4.63–9.58] | 3.41 [2.71–4.31] | 91.4 [86.3–94.6] | <0.001 | 0.979 | ||||
RBG | 1 | 1217 | 6 | 0.49 [0.16–0.98] | − | − | − | |||||
HbA1c | 3 | 2463 | 113 | 3.96 [1.32–7.87] | 3.30 [2.04–5.34] | 90.8 [76.0–96.5] | <0.001 | 0.831 | ||||
Mixed criteria | 7 | 5867 | 179 | 3.48 [2.42–4.72] | 2.11 [1.46–3.05] | 77.6 [53.4–89.2] | <0.001 | 0.102 | ||||
ART duration | ||||||||||||
Median duration of ART use = 4.5 years | On ART for ≥4.5 years | Any criteria | 12 | 9824 | 514 | 4.56 [2.77–6.74] | 4.21 [3.49–5.07] | 94.4 [91.8–96.1] | <0.001 | 0.031 | 0.550 | 0.570 |
Biochemical criteria only | <0.001 | |||||||||||
OGTT | 1 | 150 | 27 | 18.00 [12.23–24.59] | <0.001 | |||||||
FBG | 4 | 977 | 51 | 4.41 [2.16–7.35] | 1.87 [1.11–3.15] | 71.3 [18.1–89.9] | 0.015 | − | 0.355 | |||
RBG | 1 | 270 | 33 | 12.22 [8.56–16.42] | − | − | − | − | ||||
HbA1c | 2 | 497 | 33 | 6.57 [4.52–8.96] | 1.00 | 00.0 | 0.872 | − | ||||
Mixed criteria | 1 | 1316 | 1 | 0.15 [0.00–0.46] | − | − | − | 0.001 | ||||
Self‐report | 0.096 | |||||||||||
Self‐report | 3 | 1856 | 63 | 5.48 [1.63–11.29] | 3.69 [2.35–5.81] | 92.7 [81.9–97.0]‐ | <0.001 | 0.101 | 0.102 | |||
Patient folder | 2 | 1415 | 30 | 2.10 [1.40–2.93] | 1.00 | 00.0 | 0.962 | 0.280 | ||||
Biochemical criteria and/or self‐report | 0.005 | |||||||||||
OGTT | 1 | 240 | 2 | 0.83 [0.01–2.50] | − | − | − | <0.001 | ||||
FBG | 4 | 5844 | 379 | 6.35 [2.96–10.87] | 4.64 [3.34–6.45] | 95.4 [91.0–97.6] | <0.001 | 0.960 | 0.839 | |||
HbA1c | 1 | 379 | 4 | 1.06 [0.22–2.39] | − | − | − | <0.001 | ||||
Mixed criteria | 2 | 1916 | 61 | 3.50 [1.36–6.56] | 2.92 [1.49–5.72] | 88.3 [55.2–96.9] | 0.003 | 0.255 | ||||
On ART for <4.5 years | Any criteria | 12 | 7191 | 300 | 3.68 [1.89–5.99] | 4.37 [3.65–5.24] | 94.8 [92.5–96.4] | <0.001 | 0.234 | 0.725 | ||
Biochemical criteria only | 0.336 | |||||||||||
OGTT | 4 | 926 | 22 | 2.28 [1.14–3.75] | 1.21 [1.00–2.02] | 31.7 [0.0–75.5] | 0.222 | 0.450 | ||||
Mixed criteria | 1 | 1166 | 21 | 1.80 [1.11–2.65] | − | − | − | |||||
Self‐report | 0.325 | |||||||||||
Self‐report | 2 | 1624 | 28 | 1.90 [0.66–3.74] | 2.06 [1.00–4.32] | 76.5 [0.0–94.6] | 0.039 | |||||
Patient folder | 1 | 502 | 15 | 2.99 [1.66–4.68] | − | − | − | |||||
Biochemical criteria and/or self‐report | <0.001 | |||||||||||
OGTT | 1 | 332 | 25 | 7.53 [4.91–10.64] | − | − | − | |||||
FBG | 3 | 1234 | 95 | 6.16 [0.85–15.63] | 5.50 [3.84–7.89] | 96.7 [93.2–98.4] | <0.001 | 0.633 | ||||
RBG | 1 | 1502 | 7 | 0.47 [0.17–0.89] | − | − | − | |||||
HbA1c | 2 | 786 | 59 | 7.48 [5.73–9.44] | 1.00 | 00.0 | 0.439 | |||||
Mixed criteria | 5 | 3861 | 217 | 5.61 [3.38–8.35] | 2.31 [1.70–3.14] | 81.3 [65.6–89.9] | <0.001 | 0.786 |
Abbreviations: FBG, fasting blood glucose; OGTT, oral glucose tolerant test; RBG, random blood glucose.
– not computable.