Skip to main content
. Author manuscript; available in PMC: 2023 Mar 16.
Published in final edited form as: Clin Sci (Lond). 2022 Mar 18;136(5):345–360. doi: 10.1042/CS20210512

Figure 3. Mitochondria-mediated mechanisms of disease progression in ADPKD.

Figure 3.

In ADPKD, polycystin-1 deficiency is associated with changes in the expression of mitochondria-associated endoplasmic reticulum membranes (MAMs) and impaired mitochondrial calcium uptake. Peroxisome proliferator-activated receptor γ coactivator (PGC-1α) expression, the main regulator of mitochondrial biogenesis is also suppressed. Expression of NOX-4 increases, whereas expression of SOD-2 decreases, creating a vicious cycle of excessive ROS generation and impaired antioxidant defenses that aggravates mitochondrial damage.