Table 1.
Comparative table of the results obtained from the diagnostic test for COVID-19 based on the search for specific IgG antibodies in urine and serum.
| rSARS-CoV-2 antigen | Sample | n | AUC | P value | Cut-off | Se | 95%CI | Sp | 95%CI | J |
|---|---|---|---|---|---|---|---|---|---|---|
| Euk1-S1 | URINE | + 140/–31 | 0.8979 | < 0.0001 | > 1.035 | 67.14 | 58.70% to 74.84% | 96,77 | 83.30% to 99.92% | 0.64 |
| SERUM | + 140/–46 | 0.9151 | < 0.0001 | > 1.150 | 81.43 | 73.98% to 87.50% | 97.83 | 88.47% to 99.94% | 0.79 | |
| Prok1-S1 | URINE | + 140/–31 | 0.9340 | < 0.0001 | > 1.015 | 80.71 | 73.19% to 86.89% | 93.55 | 78.58% to 99.21% | 0.74 |
| SERUM | + 140/–46 | 0.8443 | < 0.0001 | > 1.020 | 62.86 | 54.29% to 70.87% | 95.65 | 85.16% to 99.47% | 0.58 | |
| Prok2-S1 | URINE | + 140/–31 | 0.9798 | < 0.0001 | > 1.065 | 89.29 | 82.94% to 93.88% | 96.77 | 83.30% to 99.92% | 0.86 |
| SERUM | + 140/–46 | 0.7696 | < 0.0001 | > 1.010 | 40.00 | 31.82% to 48.61% | 97.83 | 88.47% to 99.94% | 0.38 |
Samples from symptomatic patients for Covid-19 and with PCR + for SARS-COV-2, as well as from healthy individuals pre-exposed to the virus were used. The individual index (I) value obtained by the Abs / cut-off ratio were used to construct ROC curves. The diagnostic performance of the antigen in relation to the type of sample used was based on the evaluation of sensitivity (95% CI), specificity (95% CI), area on the curve (AUC) and Youden index (J). Legend: J = (Se + Sp)–1; n = samples number, + = positive sample, − = negative sample.