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. 2023 Mar 16;13:4348. doi: 10.1038/s41598-023-30421-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Regulation of coagulation and vessel perfusion post-CCI. (a,b) Western blotting of Fibrin-Beta-2 6 h post-CCI, blots were revealed by near infrared laser scanning, quantification was performed with ImageJ, indicating decreased expression following LD DNase-I treatment compared to vehicle (n = 5 mice/group). (c,d) Characterization of thrombus formation using cast material injection and micro-CT imaging (n = 3 mice/group). The area of non-perfused brain tissue (red shading) did not differ significantly between treatment groups. A significance level p < 0.05 is marked with *, p < 0.01 with **, and p < 0.001 with ***. All data are presented as mean ± SEM; p values are adjusted for multiple comparisons by Sidak correction.