Table 3.
Significant clusters with reduced cholinergic binding in dementia with Lewy bodies (DLB) compared to normal elderly
| Clustera (voxels) | p-valueb | Peak MNI Coordinates | z-value | t-value | Peak Voxel locationc | Predominant Network Hubd | ||
|---|---|---|---|---|---|---|---|---|
| X | Y | Z | ||||||
| 2172 | p<0.001 | −28 | −18 | 18 | 4.84 | 6.18 | Left Hippocampus peak with cluster extending into LGN | Spatial Navigation & Visual Attention networks |
| 6116 | p<0.001 | −58 | −6 |
−4 | 6.24 | 9.482 | Left BA22 peak with cluster extending into insula | Cingulo-opercular & Saliency networks |
| 7726 | p<0.001 | 52 | 4 | 34 | 5.50 | 7.566 | Right BA6 peak with cluster extending into insula | Cingulo-opercular & Saliency networks |
| 274 | p<0.001 | −4 | 32 | −8 | 3.90 | 4.642 | Left BA32 (Anterior cingulum) | Cingulo-opercular network |
| 213 | p<0.001 | 19 | 2 | 18 | 3.91 | 4.684 | Right Caudate with cluster extending into fornix | Spatial Navigation network |
a
Significant cluster extending to key areas.
b
Corrected peak-wise false discovery rate (FDR).
c
brain region with peak t-values and the extending key regions for that cluster.
d
Key large scale neural network hubs that overlap with the significant clusters.
BA: Brodmann area; LGN: Lateral geniculate nucleus; MNI: Montreal Neurological Institute.