O-GlcNAc
|
OGT |
O-GLCNAC, HRNT1, MGC22921, FLJ23071, OGT1 |
hsa-miR-485-5p36, 39, hsa-miR-10135, hsa-miR-48337, hsa-miR-200a/200b-3p38, hsa-miR-24-140, hsa-miR-42442, hsa-miR-423-5p44, hsa-miR-746
|
OGA |
MGEA5, MEA5, NCOAT |
hsa-miR-53947
|
N-linked pathway
|
|
|
|
Glycosyltransferases
|
RPN2 |
SWP1, RPNII, RIBIIR, RPN-II |
hsa-miR-12876, hsa-miR-37877
|
ALG3 |
NOT56L, Not56, CDGS4, D16Ertd36e |
hsa-miR-34278
|
ALG12 |
ECM39, CDG1G |
hsa-miR-147a79
|
ALG13 |
GLT28D1, CXorf45, CDG1S |
hsa-miR-34a80
|
FUT8 |
|
hsa-miR-1229, hsa-miR-34a9, hsa-miR-26a53, has-miR-26b53, hsa-miR-146a8, hsa-miR-198 69
|
MGAT3 |
GNT-III |
hsa-miR-23a 81
|
MGAT4A |
GnT-Iva, GnT-4a |
hsa-miR-42442, hsa-let-7c50
|
Glycosidases
|
EDEM1 |
KIAA0212, EDEM |
hsa-miR-211 82, hsa-miR-581 83, 84, hsa-miR-204 83, 84
|
MAN1A2 |
MAN1B |
hsa-miR-30c, hsa-miR-3614
|
MAN1B1 |
|
hsa-miR-125b85, 86
|
MANEA |
FLJ12838 |
hsa-miR-120287
|
O-linked pathway
|
|
|
|
Initiation
|
GALNT1 |
GalNAc-T1 |
hsa-miR-216b21, hsa-miR-30b/30d10, hsa-miR-10a88, hsa-miR-12920
|
GALNT2 |
GalNAc-T2 |
hsa-let-7b89
|
GALNT3 |
GalNAc-T3, HHS, HFTC |
hsa-miR-26a90, hsa-miR-17-3p and hsa-miR-22191
|
GALNT4 |
GalNAc-T4 |
hsa-miR-426292, hsa-miR-993, hsa-miR-36594
|
GALNT5 |
GalNAc-T5 |
hsa-miR-196b-5p95
|
GALNT7 |
GalNAc-T7 |
hsa-miR-15418, hsa-miR-21411, 17, hsa-miR-30a-5p16, hsa-miR-49414, 15, hsa-miR-34a/c13, hsa-miR-17-3p/5p12, hsa-miR-21411, 17,hsa-miR-30b/30d10, hsa-miR-378 10–19
|
GALNT10 |
GalNAc-T10 |
hsa-miR-12296
|
GALNT13 |
GalNAc-T13, KIAA1918 |
hsa-miR-42442
|
GALNT14 |
GalNAc-T14, FLJ12691 |
hsa-miR-125a97
|
TMTC2 |
DKFZp762A217 |
hsa-miR-14298
|
POGLUT1 |
KDELCL1, MDS010, MDS010, MGC32995, 9630046K23Rik, MDSRP, hCLP46, Rumi |
hsa-miR-13499, hsa-miR-14299, 100
|
Elongation and Branching
|
B3GAT3 |
GlcAT-I |
hsa-miR-23b101
|
B3GLCT |
B3GALTL |
hsa-miR-200b, hsa-miR-200c, hsa-miR-4293
|
B3GNT5 |
B3GN-T5, beta3Gn-T5 |
hsa-miR-203102
|
C1GALT1 |
C1GALT, T-synthase |
hsa-miR-148b103
|
C1GALT1C1 |
COSMC, C1GALT2 |
hsa-miR-320104, hsa-miR-155105, hsa-miR-374b106
|
GCNT2 |
NACGT1, II, GCNT5, CCAT, IGNT, NAGCT1, bA421M1.1, bA360O19.2, ULG3 |
hsa-miR-199a/b-5p 107
|
GCNT3 |
C2GnT-M, C2/4GnT, C2GnT2 |
hsa-miR-302b-3p 108, hsa-miR-15b 109
|
LFNG |
SCDO3 |
hsa-miR-200f 110, hsa-miR-125a-5p 111, 112, hsa-miR-146a 113
|
Capping
|
|
|
|
PolyLacNAc
|
B3GALT5 |
beta3Gal-T5, B3GalT-V, GLCT5, B3T5 |
hsa-miR-203114
|
B4GALT1 |
GGTB2 |
hsa-miR-124-3p115
|
Sialylation
|
ST3GAL3 |
ST3Gal III, SIAT6, MRT12 |
hsa-miR-200a116
|
ST3GAL4 |
STZ, SAT3, FLJ11867, CGS23, SIAT4, NANTA3, SIAT4C |
hsa-miR-200a116, hsa-miR-370113
|
ST3GAL5 |
SIAT9, ST3GalV, SIATGM3S |
hsa-miR-26a117, hsa-miR-548l117, hsa-miR-34a117, hsa-miR-200b3, hsa-miR-200c3, hsa-miR-4293
|
ST3GAL6 |
SIAT10, ST3GALVI |
hsa-miR-26a118, 119
|
ST6GAL1 |
SIAT1, ST6Gal I |
hsa-miR-9120
|
ST6GALNAC1 |
SIAT7A, ST6GalNAcI |
hsa-miR-30d-5p121
|
ST6GALNAC2 |
SIAT7, SIAT7B, SIATL1 |
hsa-miR-182122, 123, hsa-miR-135b122, 123
|
ST6GALNAC4 |
SIAT7D, ST6GALNACIV, SIAT3C |
hsa-miR-4299124
|
ST6GALNAC5 |
SIAT7E, MGC3184, ST6GalNAcV |
hsa-miR-200b, hsa-miR-200c, hsa-miR-4293
|
ST8SIA1 |
SIAT8, SIAT8A |
hsa-miR-33a,hsa- let-7e125
|
ST8SIA2 |
SIAT8B, STX, ST8SIA-II, HsT19690 |
hsa-miR-3099126
|
ST8SIA4 |
SIAT8D, ST8Sia IV |
hsa-miR-26a/26b127, hsa-miR-146a/146b128, hsa-miR-181c128
|
Fucosylation
|
FUT1 |
H, HSC |
hsa-miR-140-5p129, hsa-miR-149 129, hsa-miR-34a 130
|
FUT2 |
SE, sej, Se2, SEC2 |
hsa-miR-15b 131
|
FUT4 |
CD15, FUC-TIV, FCT3A, ELFT |
hsa-miR-125a-5p 129, hsa-miR-26a/26b 53, 56, hsa-miR-200c 55, hsa-miR-200b 55, hsa-miR-493-5p 52, hsa-miR-224-3p 51
|
FUT5 |
FUC-TV |
hsa-miR-125a-3p 132
|
FUT6 |
FT1A, FCT3A, FucT-VI, FLJ40754 |
hsa-miR-326 133, hsa-miR-125a-3p 132, hsa-miR-106b 133
|
FUT8* |
See above in N-linked pathway |
|
GAG related enzymes
|
|
|
|
Chondroitin Sulfate Synthetases
|
CHSY1 |
KIAA0990, CSS1
|
has-miR-194, hsa-miR-515134
|
CHPF |
CSS2, CHSY2 |
has-miR-194, hsa-miR-515134
|
CHSY3 |
CSS3, CHSY-2 |
has-miR-194, hsa-miR-515134
|
Glucuronyl acid epimerase
|
GLCE |
KIAA0836, HSEPI |
hsa-miR-218135
|
Sulfotransferases/sulfatases
|
CHST3 |
C6ST, C6ST1 |
hsa-miR-513a-5p 136
|
HS3ST2 |
3OST2 |
hsa-miR-100 137
|
HS6ST2 |
|
hsa-miR-141-3p, hsa-miR-145-5p 138
|
NDST1 |
HSST, NST1 |
hsa-miR-149139, hsa-miR-24139, hsa-miR-191139
|
SULF1 |
KIAA1077, SULF-1, hSulf-1 |
hsa-miR-21140
|
Hyaluronan synthetases
|
HAS1 |
HAS |
hsa-miR-125a141, hsa-miR-214141
|
HAS2 |
|
hsa-miR-410 (up-regulating) 142, hsa-miR-7143, hsa-miR-26b144, hsa-miR-378144, hsa-miR-23a-3p 145, hsa-miR-424/424*146, hsa-miR-23147, hsa-miR-574147, hsa-miR-101-3p148
|
HAS3 |
|
hsa-miR-26a-5p149, hsa-miR-29a-3p150
|
Others
|
|
|
|
Glycosidases
|
FUCA2 |
MGC1314, dJ20N2.5 |
hsa-miR-145151, hsa-miR-200b, hsa-miR-200c, hsa-miR-429 4
|
GALC |
|
hsa-miR-140-5p152
|
GBA |
GLUC, GBA1 |
hsa-miR-22-3p153
|
NEU1 |
NEU |
hsa-miR-125b154
|
HEXB |
|
hsa-miR-207, hsa-miR-352 155
|
Nucleotide Sugar Metabolism
|
PMM2 |
CDG1, CDGS, CDG1a, PMI, PMI1 |
hsa-miR-451a156, 157
|
TSTA3 |
FX, P35B, SDR4E1 |
hsa-miR-125a-5p, hsa-miR-125b158
|
CMAHP |
CMAH |
hsa-miR-155-5p, hsa-miR-425-5p, hsa-miR-15a-5p, hsa-miR-503-5p, hsa-miR-16-5p, hsa-miR-29a-3p, and hsa-miR-29b-3p159
|
UAP1 |
SPAG2, AGX1, AgX |
hsa-miR-224-5p 160
|
Nucleotide sugar transporters
|
SLC35B2 |
PAPST1, UGTrel4 |
hsa-miR-22161
|
SLC35B4 |
FLJ14697, YEA4 |
hsa-miR-1764, hsa-miR-1700162
|
SLC35F5 |
FLJ22004 |
hsa-miR-369-3p 163
|
UDP-Glucuronyltransferases (involved in Drug Metabolism)
|
UGT2B15 |
UGT2B8 |
hsa-miR-331-5p164, 165, hsa-miR-376c 166, hsa-miR-770-5p 165, hsa-miR-103b 165, hsa-miR-3924 165, hsa-miR-376b-3p 165, hsa-miR-455-5p, 165 hsa-miR-605 165, hsa-miR-624-3p 165, hsa-miR-4712-5p 165, hsa-miR-3675-3p 165, hsa-miR-6500-5p 165, hsa-miR-548as-3p 165, hsa-miR-4292 165
|
UGT2B17 |
|
hsa-miR-376c 166
|
UGT2B7 |
UGT2B9 |
hsa-miR-1293, hsa-miR-3664-3p, hsa-miR-4317, hsa-miR-513c-3p, hsa-miR-4483, and hsa-miR-142-3p 164, 167
|
Other Glycosylation Related Proteins
|
COG6 |
COD2, KIAA1134 |
hsa-miR-1 168
|
KL (Klotho) |
|
hsa-miR-34a169, hsa-miR-199b-5p170, 171, hsa-miR-504172, hsa-miR-339172, hsa-miR-556173
|
SPOCK1 |
TIC1, SPOCK, testican-1 |
hsa-miR-150-3p/5p 174, 175, hsa-miR-129-5p 174, hsa-miR-585 175
|
SPOCK3 |
testican-3 |
hsa-miR-145176
|