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. Author manuscript; available in PMC: 2023 Mar 16.
Published in final edited form as: J Orthop Sports Med. 2023 Feb 6;5(1):32–40. doi: 10.26502/josm.511500076

Figure 1:

Figure 1:

Interaction of Tumor cells with various immune cells. Tumor cells release tumor antigen which is taken up by the Dendritic Cells (DCs) to present to CD4+ T cells followed by the activation of CD8+ T cells. NK cells, B cells, T-Regulatory Cells (TREG) and Myeloid Suppressor Cells (MDSC) in the tumor microenvironment regulate the activation and function of DCs, CD8+ T cells and tumor cell. Expression of regulatory T cells and immune checkpoint proteins allow the tumor to evade the immune response.