Table 3.

The results of univariate analysis

Variable	Incident renal composite endpoint		Annual eGFR decline (mL/min/1.73 m2/year)
	HR (95%CI)	P value	β (95% CI)	P value
Age (years)	0.99 (0.98, 1.00)	0.051	-0.03 (-0.05, -0.00)	< 0.05
Gender
Male	Ref		Ref
Female	0.99 (0.74, 1.32)	0.94	-1.00 (-1.78, -0.23)	< 0.05
Etiology of CKD
Diabetic nephropathy,	Ref		Ref
Nephrosclerosis,	0.20 (0.14, 0.28)	< 0.001	-3.86 (-4.72, -2.99)	< 0.001
Glomerulonephritis	0.32 (0.22, 0.46)	< 0.001	-3.01 (-4.04, -1.99)	< 0.001
Other	0.21 (0.13, 0.33)	< 0.001	-4.64 (-5.73, -3.55)	< 0.001
BMI (kg/m2)	1.02 (0.99, 1.06)	0.19	-0.01 (-0.10, 0.08)	0.85
SBP (mmHg)	1.02 (1.01, 1.02)	< 0.001	0.05 (0.04, 0.07)	< 0.001
HB (g/dL)	0.70 (0.66, 0.75)	< 0.001	-0.28 (-0.45, -0.12)	< 0.001
Scr (mg/dL)	1.43 (1.37, 1.49)	< 0.001	0.21 (-0.04, 0.46)	0.11
eGFR (ml/min per 1.73 m2)	0.92 (0.91, 0.93)	< 0.001	-0.02 (-0.04, 0.002)	0.07
ALB (g/dL)	0.34 (0.29, 0.41)	< 0.001	-3.37 (-3.93, -2.81)	< 0.001
Urinary occult blood
No	Ref		Ref
Yes	1.57 (1.20, 2.06)	< 0.05	1.68 (0.92, 2.43)	< 0.001
UPCR(g/gCr)	1.20 (1.17, 1.23)	< 0.001	0.74 (0.64, 0.84)	< 0.001
Hypertension
No	Ref		Ref
Yes	4.06 (1.80, 9.13)	< 0.001	1.81 (0.59, 3.03)	< 0.05
History of CVD
No	Ref		Ref
Yes	1.25 (0.93, 1.68)	0.13	0.33 (-0.49, 1.15)	0.43
Diabetes
No	Ref		Ref
Yes	2.49 (1.90, 3.25)	< 0.001	1.78 (1.05, 2.51)	< 0.001
Use of RAAS inhibitor
No	Ref		Ref
Yes	1.72 (1.26, 2.36)	< 0.001	1.50 (0.75, 2.26)	< 0.001
Use of calcium channel blocker
No	Ref		Ref
Yes	1.73 (1.32, 2.28)	< 0.001	0.61 (-0.11, 1.32)	0.10
Use of diuretics
No	Ref		Ref
Yes	2.19 (1.68, 2.86)	< 0.001	1.55 (0.79, 2.32)	< 0.001
CKD stage
2	Ref		Ref
3	1.63 (0.58, 4.58)	0.35	-0.41 (-1.77, 0.95)	0.55
4	6.27 (2.30, 17.06)	< 0.001	0.37 (-1.02, 1.77)	0.60
5	21.88 (8.02, 59.68)	< 0.001	0.41 (-1.14, 1.96)	0.61