Table 2.
Linear mixed model results of MCI and Dementia groups for plasma TG/HDL ratios and ApoA1 levels, and CSF ApoA1 levels
| MCI group | Dementia group | |||
|---|---|---|---|---|
| Effect |
Slope (95% CI) |
p-value |
Slope (95% CI) |
p-value |
| MMSE | ||||
| CSF ApoA1 |
0.204 (0.030,0.377) |
0.022 |
− 0.683 (− 1.525,0.159) |
0.11 |
| Plasma ApoA1 |
− 0.498 (− 0.744, − 0.253) |
< 0.001 |
− 1.546 (− 3.080, − 0.012) |
0.048 |
| TG/HDL ratio |
− 0.127 (− 0.251, − 0.004) |
0.043 |
− 0.299 (− 1.063, 0.466) |
0.44 |
| CDR-SB | ||||
| CSF ApoA1 |
− 0.025 (− 0.148, 0.099) |
0.69 |
0.112 (− 0.383, 0.607) |
0.65 |
| Plasma ApoA1 |
0.141 (− 0.041, 0.324) |
0.13 |
0.784 (− 0.118, 1.686) |
0.088 |
| TG/HDL ratio |
0.116 (0.024, 0.207) |
0.013 |
0.472 (0.023, 0.921) |
0.040 |
| LM | ||||
| CSF ApoA1 |
− 0.002 (− 0.144, 0.140) |
0.97 |
0.203 (− 0.145, 0.550) |
0.25 |
| Plasma ApoA1 |
− 0.303 (− 0.502, − 0.103) |
0.003 |
− 0.424 (− 1.053, 0.204) |
0.18 |
| TG/HDL ratio |
0.009 (− 0.091,0.109) |
0.87 |
0.141 (− 0.182, 0.464) |
0.39 |
MMSE, Mini-Mental Status Exam score; CDR-SB, Clinical Dementia Rating Scale–Sum of Boxes score; LM, logical memory delayed recall score. Positive slope notes faster progression CDR-SB; negative slope notes faster progression in MMSE and LM