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. 2023 Mar 16;15:54. doi: 10.1186/s13195-023-01203-y

Table 6.

Summary of Linear mixed model results of MCI and Dementia groups and by APOE ε4 status for plasma TG/HDL ratio and ApoA1, and CSF ApoA1 levels

Analyte All MCI (n = 106) MCI APOE4 positive (n = 58) MCI
APOE4 negative
(n = 48)
All dementia (n = 50) Dementia APOE4 positive (n = 36) Dementia
APOE4 negative
(n = 14)
Plasma TG/HDL Faster Faster N.S Faster Faster N.S
Plasma ApoA1 Faster Faster Faster Faster Faster Faster
CSF ApoA1 Slower Faster N.S N.S Faster N.S

Faster: Higher baseline analyte levels relate to faster progression in one or more of the three cognitive scores: MMSE, CDR-SB, LM

Slower: Higher baseline analyte levels relate to slower progression in one or more of the three cognitive scores: MMSE, CDR-SB, LM

N.S Non-significant results