Table 7.

Linear mixed model results of the MCI and dementia groups stratified by APOE ε4 status

	MCI group				Dementia group
	APOEε4 positive (n = 58)		APOEε4 negative (n = 48)		APOEε4 positive (n = 36)		APOEε4 negative (n = 14)
Effect	Slope (95% CI)	p-value	Slope (95% CI)	p-value	Slope (95% CI)	p-value	Slope (95% CI)	p-value
MMSE
CSF ApoA1	− 0.059 (0.302, 0.183)	0.63	0.233 (− 0.024, 0.489)	0.075	− 1.029 (− 1.950, − 0.108)	0.029	1.078 (− 0.205, 2.361)	0.097
Plasma ApoA1	− 0.798 (− 1.258, − 0.339)	< 0.001	− 0.474 (− 0.740, − 0.209)	< 0.001	− 1.715 (− 3.285, − 0.146)	0.033	− 0.794 (− 3.923, 2.336)	0.61
Plasma TG/HDL	− 0.327 (− 0.562, − 0.093)	0.006	− 0.044 (− 0.173, 0.084)	0.50	− 0.559 (− 1.279, 0.162)	0.13	0.960 (− 1.045, 2.965)	0.34
CDR-SB
CSF ApoA1	0.220 (0.057, 0.383)	0.008	0.076 (− 0.113, 0.264)	0.43	0.137 (− 0.451, 0.725)	0.64	− 0.474 (− 1.245, 0.297)	0.22
Plasma ApoA1	0.518 (0.199, 0.838)	0.002	− 0.032 (− 0.229, 0.164)	0.75	0.656 (− 0.346, 1.658)	0.19	0.729 (− 1.151, 2.609)	0.44
TG/HDL	0.287 (0.126, 0.448)	< 0.001	0.057 (− 0.038, 0.152)	0.24	0.580 (0.120, 1.040)	0.014	− 0.112 (− 1.316, 1.093)	0.85
LM
CSF ApoA1	0.017 (− 0.156, 0.190)	0.84	0.093 (− 0.163, 0.350)	0.47	0.042 (− 0.282, 0.366)	0.79	0.613 (− 0.008, 1.234)	0.053
Plasma ApoA1	0.220 (− 0.108, 0.549)	0.19	− 0.598 (− 0.866, − 0.330)	< 0.001	0.068 (− 0.479, 0.615)	0.80	− 2.753 (− 4.268, − 1.239)	< 0.001
Plasma TG/HDL	0.125 (− 0.044, 0.293)	0.15	0.002 (− 0.127, 0.130)	0.98	0.142 (− 0.117, 0.402)	0.28	− 0.548 (− 1.518, 0.423)	0.26

MMSE Mini-Mental Status Exam score, CDR-SB Clinical Dementia Rating Scale–Sum of Boxes score, LM Logical memory delayed recall score. Positive slope notes faster progression CDR-SB, negative slope notes faster progression in MMSE and LM