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. 2023 Mar 16;24(1):26. doi: 10.1186/s10194-023-01560-x

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Galcanezumab effects on incidence of headache after occurrence of premonitory symptoms in responders and non-responders. A Incidence of all premonitory symptoms that were followed by headache decrease by the galcanezumab treatment in both, responders and non-responders. Note that after occurrence of premonitory symptoms, responders experienced significantly less headaches than non-responders (p = 0.004, DF = 1, Fisher exact). B Incidences of headache following occurrence of each of the 9 most common premonitory symptoms (i.e., premonitory symptoms that prior to treatment were followed by headache in > 20% of all patients) during the 3-month treatment period. The 100% (in A and B) represents incidences of all (A) and individual (B) premonitory symptoms that were followed by headache prior to treatment initiation