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. 2023 Mar 16;25:42. doi: 10.1186/s13075-023-03022-w

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — FMT-Lpr mice have altered intestinal permeabilities and immunological states. Representative images of HE staining of the small intestine (A) and the large intestine (B). Scale bar, 50 μm. magnification × 400. ZO-1 expressions detected by immunofluorescence and the mRNA levels measured by RT-PCR in the small intestine (C) and the large intestine (D). Tnf, Il18, and Ifng mRNA expression levels in the small intestine (E) and Il6, Tnf, Il18, and Ifng mRNA expression levels in the large intestine (F). Flow cytometric analysis of the percentages of CD11b + cells gated on the CD45 + CD3 − CD19 − cells in the small intestine (G) and the percentages of B220 − IgD − CD138 + cell characterized as the plasma cells gated on the CD45 + cells in the large intestine (H). *p < 0.05. **p < 0.001. FMT-Lpr, n = 8 ~ 11; FMT-Mpj, n = 5 ~ 10; FMT-PBS, n = 5 ~ 7