Table 1 |.
Human NK cell receptors and reported ligands
| Receptors | Functions | Ligands |
|---|---|---|
| NKG2D | activating | MICA, MICB, ULBP1–6 |
| DNAM-1 | activating | Nectin-2 (CD112), PVR (CD155) |
| FcγRIIIa (also known as CD16) | activating | Fc domains of IgG1 and IgG3 |
| NKp80 | activating | AICL |
| NKG2C/CD94 | activating | HLA-E |
| SLAMF7 | activating | SLAMF7 |
| KIR2DS1 | activating | Group 2 HLA-C |
| KIR2DS4 | activating | Some HLA-C, HLA-A*11, HLA-F |
| KIR3DS1 | activating | HLA-Bw4, HLA-F |
| TM1GD2 (CD28H) | activating | HHLA2 |
| NKp30 (NCR3) | activating | B7-H6, HLA-B associated transcript 3 (BAT3)/ Bcl2-associated anthogene 6 (BAG6) (soluble/exosomes), galectin-3, heparan sulfate proteoglycans |
| NKp46 (NCR1) | activating | hemagglutinins, heparan sulfate proteoglycans, vimentin, complement factor P (CFP; properdin, soluble) |
| NKp44 (NCR2) | activating | 21spe-MLL5 (splice variant of MLL5), heparan sulfate proteoglycans, PDGF-DD (soluble), some HLA-DP, hemagglutinins, Nidogen-1, Dengue virus E protein |
| inhibitory | PCNA, Nidogen-1 (soluble) | |
| 2B4 | activating/ inhibitory | CD48 |
| KIR2DL1 | inhibitory | Group 2 HLA-C |
| KIR2DL2, KIR2DL3 | inhibitory | Group 1 HLA-C, some group 2 HLA-C, some HLA-B |
| KIR2DL5 | inhibitory | PVR |
| KIR3DL1 | inhibitory | HLA-Bw4 containing alleles of HLA-B and HLA-A |
| KIR3DL2 | inhibitory | some HLA-A (such as A*03 and A*11), HLA-F |
| KIR3DL3 | inhibitory | HHLA2 |
| NKG2A/CD94 | inhibitory | HLA-E |
| NKR-P1A | inhibitory | CLEC2D (LLT1) |
| LILRB1 (ILT2, LIR1) | inhibitory | HLA-A, HLA-B, HLA-C, HLA-G, HLA-F, S100A9 |
| KLRG1 | inhibitory | E-cadherin, N- cadherin, and R-cadherin |
| CD96 (TACTILE) | inhibitory | Nectin-1 (CD111), PVR |
| TIGIT | inhibitory | Nectin-2, PVR |
| PVRIG | inhibitory | Nectin-2 |
| TIM-3 | inhibitory | Galectin-9, CEACAM-1, phosphatidyl serine, HMGB1 |
| LAG-3 | inhibitory | MHC class II, galectin-3, LSECtin (liver sinusoidal endothelial cell lectin), FGL1 |
| PD-1 | inhibitory | PD-L1, PD-L2 |
Abbreviations: AICL, activation-induced C-type lectin; LAG-3; PVR, PD-1, PD-L1, PVRIG ; TIGIT; TIM-3