Table 1.
Frequency of non-synonymous mutations within the P1 region. Summary of the emergence of non-synonymous mutations within the structural region of virus. NGS was carried out, and mutation frequency is represented as a percentage of total reads at a given site
|
VP2 V85L |
VP3 I235M |
VP1 Y116C |
VP1 K162I |
VP1 P246A |
|
|---|---|---|---|---|---|
|
Untreated |
− |
− |
− |
− |
+ |
|
Passage 4 |
24.3 |
95.5 |
2.3 |
15.6 |
95.2 |
|
Passage 5 |
14.5 |
97.2 |
2.3 |
21.2 |
97.2 |
|
Passage 7 |
9.2 |
100 |
22.8 |
99.6 |
100 |
|
Passage 8 |
20.6 |
99.6 |
43.5 |
99.9 |
99.7 |
|
Passage 9 |
43.1 |
99.7 |
69.5 |
99.9 |
99.7 |