Table 4.

Emitted dose, fine particle fraction, emitted fine particle fraction of spray dried formulations (mean ± standard deviation, n=3)

Formulation	Drug	Emitted Dose (%)	Fine Particle Fraction (%)	Emitted Fine Particle Fraction (%)
Colistin alone	Colistin	88.9 ± 1.7	79.9 ± 2.4	89.9 ± 1.0
1:1 Col a -Tob b	Colistin	90.8 ± 1.1	85.2 ± 0.9 *	93.9 ± 3.2 *
	Tobramycin	89.5 ± 0.5 #	83.29 ± 1.3 #	93.1 ± 0.7 #
1:5 Col-Tob	Colistin	90.6 ± 0.5	84.8 ± 2.8	93.6 ± 2.7 *
	Tobramycin	89.6 ± 0.8 #	82.7 ± 0.7 #	92.3 ± 1.0 #
Tobramycin alone	Tobramycin	56.0 ± 3.3	44.7 ± 2.4	79.9 ± 1.6

^*indicates significant difference compared to the spray dried colistin alone, p < 0.05.

^#indicates significant difference compared to the spray dried tobramycin alone, p < 0.05.

^aCol – colistin

^bTob – tobramycin