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. 2023 Jan 20;7(2):e0018. doi: 10.1097/HC9.0000000000000018

FIGURE 1.

FIGURE 1

PROM1 expression in the PBGs of murine EHBD. (A) Whole mount imaging of PROM1 (red) and KRT19 (green) of a cleared adult EHBD. PROM1 expression is seen in the EHBD PBGs. Triangles point to PBGs. Scale bar, 100 μm. (B) RNA in situ hybridization demonstrates Prom1 (red) and Krt19 (green) co-expression PBGs. White box indicates zoomed-in insets. Nuclei were counterstained with DAPI. Scale bar, 50 μm. (C) PROM1 is co-expressed in PBGs with biliary progenitor cell markers SOX9, SOX17, and PDX1 (green). White boxes indicate zoomed-in insets of PBGs. Scale bar, 50 μm. Abbreviations: EHBD, extrahepatic bile duct; PBG, peribiliary gland; PDX1, pancreatic and duodenal homeobox 1; PROM1, Prominin-1; SOX9, sex-determining region Y-box 9; SOX17, sex-determining region Y-box 17.