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. 2023 Jan 20;7(2):e0018. doi: 10.1097/HC9.0000000000000018

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Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Association for the Study of Liver Diseases.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/

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PROM1 is expressed in human peribiliary glands and in biliary epithelium of the portal plate in BA. Top panel demonstrates proximal EHBD tissue at the portal plate in non-BA control and BA sections. Immunohistochemical staining for PROM1 (red) and SOX9 (brown) reveal PROM1 expression in smaller diameter ducts in non-BA controls, which is absent in larger ducts. PROM1 and SOX9 are universally expressed in biliary tissue in BA portal plate. PROM1 is expressed in the peribiliary glands of non-BA diseased common bile duct (inset). PROM1 is not found in distal non-BA EHBD. Scale bar, 500 μm. Abbreviations: BA, biliary atresia; EHBD, extrahepatic bile duct; PROM1, Prominin-1; SOX9, sex-determining region Y-box 9.