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Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1986 Jun;45(6):484–490. doi: 10.1136/ard.45.6.484

Serum osteocalcin in rheumatoid arthritis and other inflammatory arthritides: relation between inflammatory activity and the effect of glucocorticoids and remission inducing drugs.

E A Ekenstam, S Ljunghall, R Hällgren
PMCID: PMC1001920  PMID: 3015056

Abstract

Osteocalcin, a vitamin K dependent protein synthesised by osteoblasts, was measured in serum by radioimmunoassay in patients with rheumatoid arthritis (n = 36) and seronegative spondyloarthropathies (n = 23). The serum osteocalcin levels were decreased in both patient groups compared with the levels measured in age and sex matched healthy controls. We found no relation between serum osteocalcin and the disease duration or inflammatory activity of the patients who were without drug treatment at the first examination. After administration of glucocorticoids (20 mg prednisolone a day) circulating osteocalcin decreased significantly after one week of treatment. During gradual reduction of the steroid dosage osteocalcin returned to pretreatment values. Treatment with non-steroidal anti-inflammatory drugs (NSAIDs) did not influence circulating osteocalcin. During treatment with chloroquine or penicillamine serum osteocalcin increased significantly, concomitant with a reduction of the acute phase reactants. Controversy persists about the abnormality of bone turnover in rheumatic diseases, but our data suggest that the overall bone turnover is decreased in patients with rheumatoid arthritis and other inflammatory arthritides.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beresford J. N., Gallagher J. A., Poser J. W., Russell R. G. Production of osteocalcin by human bone cells in vitro. Effects of 1,25(OH)2D3, 24,25(OH)2D3, parathyroid hormone, and glucocorticoids. Metab Bone Dis Relat Res. 1984;5(5):229–234. doi: 10.1016/0221-8747(84)90064-x. [DOI] [PubMed] [Google Scholar]
  2. Brown J. P., Delmas P. D., Malaval L., Edouard C., Chapuy M. C., Meunier P. J. Serum bone Gla-protein: a specific marker for bone formation in postmenopausal osteoporosis. Lancet. 1984 May 19;1(8386):1091–1093. doi: 10.1016/s0140-6736(84)92506-6. [DOI] [PubMed] [Google Scholar]
  3. Caniggia A., Nuti R., Lore F., Vattimo A. Pathophysiology of the adverse effects of glucoactive corticosteroids on calcium metabolism in man. J Steroid Biochem. 1981 Dec;15:153–161. doi: 10.1016/0022-4731(81)90270-3. [DOI] [PubMed] [Google Scholar]
  4. Deftos L. J., Parthemore J. G., Price P. A. Changes in plasma bone GLA protein during treatment of bone disease. Calcif Tissue Int. 1982 Mar;34(2):121–124. doi: 10.1007/BF02411221. [DOI] [PubMed] [Google Scholar]
  5. Delmas P. D., Wilson D. M., Mann K. G., Riggs B. L. Effect of renal function on plasma levels of bone Gla-protein. J Clin Endocrinol Metab. 1983 Nov;57(5):1028–1030. doi: 10.1210/jcem-57-5-1028. [DOI] [PubMed] [Google Scholar]
  6. Duncan H., Frost H. M., Villanueva A. R., Sigler J. W. The osteoporosis of rheumatoid arthritis. Arthritis Rheum. 1965 Oct;8(5):943–954. doi: 10.1002/art.1780080504. [DOI] [PubMed] [Google Scholar]
  7. Epstein S., Poser J., McClintock R., Johnston C. C., Jr, Bryce G., Hui S. Differences in serum bone GLA protein with age and sex. Lancet. 1984 Feb 11;1(8372):307–310. doi: 10.1016/s0140-6736(84)90360-x. [DOI] [PubMed] [Google Scholar]
  8. Gallop P. M., Lian J. B., Hauschka P. V. Carboxylated calcium-binding proteins and vitamin K. N Engl J Med. 1980 Jun 26;302(26):1460–1466. doi: 10.1056/NEJM198006263022608. [DOI] [PubMed] [Google Scholar]
  9. Gundberg C. M., Cole D. E., Lian J. B., Reade T. M., Gallop P. M. Serum osteocalcin in the treatment of inherited rickets with 1,25-dihydroxyvitamin D3. J Clin Endocrinol Metab. 1983 May;56(5):1063–1067. doi: 10.1210/jcem-56-5-1063. [DOI] [PubMed] [Google Scholar]
  10. Hauschka P. V., Lian J. B., Gallop P. M. Direct identification of the calcium-binding amino acid, gamma-carboxyglutamate, in mineralized tissue. Proc Natl Acad Sci U S A. 1975 Oct;72(10):3925–3929. doi: 10.1073/pnas.72.10.3925. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Helfgott S., Rosenthall L., Esdaile J., Tannenbaum H. Generalized skeletal response to 99mtechnetium methylene diphosphonate in rheumatoid arthritis. J Rheumatol. 1982 Nov-Dec;9(6):939–941. [PubMed] [Google Scholar]
  12. Price P. A., Baukol S. A. 1,25-Dihydroxyvitamin D3 increases synthesis of the vitamin K-dependent bone protein by osteosarcoma cells. J Biol Chem. 1980 Dec 25;255(24):11660–11663. [PubMed] [Google Scholar]
  13. Price P. A., Otsuka A. A., Poser J. W., Kristaponis J., Raman N. Characterization of a gamma-carboxyglutamic acid-containing protein from bone. Proc Natl Acad Sci U S A. 1976 May;73(5):1447–1451. doi: 10.1073/pnas.73.5.1447. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Price P. A., Parthemore J. G., Deftos L. J. New biochemical marker for bone metabolism. Measurement by radioimmunoassay of bone GLA protein in the plasma of normal subjects and patients with bone disease. J Clin Invest. 1980 Nov;66(5):878–883. doi: 10.1172/JCI109954. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Price P. A., Williamson M. K., Lothringer J. W. Origin of the vitamin K-dependent bone protein found in plasma and its clearance by kidney and bone. J Biol Chem. 1981 Dec 25;256(24):12760–12766. [PubMed] [Google Scholar]
  16. Reid D. M., Kennedy N. S., Smith M. A., Tothill P., Nuki G. Total body calcium in rheumatoid arthritis: effects of disease activity and corticosteroid treatment. Br Med J (Clin Res Ed) 1982 Jul 31;285(6338):330–332. doi: 10.1136/bmj.285.6338.330. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Rosenspire K. C., Kennedy A. C., Steinbach J., Blau M., Green F. A. Investigation of the metabolic acitivity of bone in rheumatoid arthritis. J Rheumatol. 1980 Jul-Aug;7(4):469–473. [PubMed] [Google Scholar]
  18. Slovik D. M., Gundberg C. M., Neer R. M., Lian J. B. Clinical evaluation of bone turnover by serum osteocalcin measurements in a hospital setting. J Clin Endocrinol Metab. 1984 Aug;59(2):228–230. doi: 10.1210/jcem-59-2-228. [DOI] [PubMed] [Google Scholar]
  19. Steven M. M., Sturrock R. D., Fogelman I., Smith M. L. Whole body retention of diphosphonate in rheumatoid arthritis. J Rheumatol. 1982 Nov-Dec;9(6):873–877. [PubMed] [Google Scholar]
  20. Tashjian A. H., Jr, Tice J. E., Sides K. Biological activities of prostaglandin analogues and metabolites on bone in organ culture. Nature. 1977 Apr 14;266(5603):645–647. doi: 10.1038/266645a0. [DOI] [PubMed] [Google Scholar]

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