FIG 3.

Simulated typical concentration-time profiles for the typical participant (11 kg and 2 years of age) (a) plasma, (b) lumbar and ventricular cerebrospinal fluid, and (c) brain extracellular fluid shown for the 2014 WHO regimen and the 2022 WHO short intensive TB meningitis regimen, as well as for the first-dose versus the steady-state (please note that true rifampicin concentrations in the brain tissue are unknown as relative recovery cannot be calculated). The dashed lines represent the MIC levels of 0.2 and 0.4 mg/L (42).