FIG 4.

Expected exposures in terms of area under the curve (${\text{AUC}}_{0-24\text{h}}$) for the typical participant (11 kg and 2 years of age) in (a) plasma, (b) lumbar and ventricular CSF, and (c) brain ECF for the 2014 WHO regimen and the 2022 WHO short intensive TB meningitis dosing recommendations, as well as, for the first-dose versus the steady-state (please note that true rifampicin concentrations in the brain tissue are unknown as relative recovery cannot be calculated). The box represents the median and interquartile range and the whiskers correspond to the 5th and 95th percentiles.