Table 1:
Baseline characteristics of patients enrolled in the E-PRISM study.
| Treatment arm |
||||
|---|---|---|---|---|
| Total | A: Elo/Len/Dex | B: Elo/Len |
p-value
|
|
| n = 51 (%) | n = 40 (78) | n = 11 (22) | ||
|
| ||||
| Aae at registration | ||||
| Median (range) | 62 (29 – 79) | 62 (29 – 79) | 62 (44 – 75) | 0.65 |
|
| ||||
| Sex | ||||
| Female | 32 (63) | 26 (65) | 6 (55) | 0.73 |
| Male | 19 (37) | 14 (35) | 5 (45) | |
|
| ||||
| Race | ||||
| Black or African American | 7 (14) | 7 (18) | - | 0.59 |
| White | 42 (82) | 31 (78) | 11 (100) | |
|
| ||||
| Ethnicity | ||||
| Non-Hispanic | 48 (94) | 37 (92) | 11 (100) | |
|
| ||||
| ECOG PS | ||||
| 00 - Fully Active | 34 (67) | 27 (68) | 7 (64) | 0.94 |
| 01 - Restricted | 16 (31) | 12 (30) | 4 (36) | |
| 02 - Ambulatory | 1 (2) | 1 (2) | - | |
|
| ||||
| Heavy chain | ||||
| IgA | 14 (27) | 10 (25) | 4 (36) | > 0.99 |
| IgG | 29 (57) | 22 (55) | 7 (64) | |
|
| ||||
| Liaht chain | ||||
| Kappa Light Chain | 2 (4) | 2 (5) | - | > 0.99 |
| Lambda Light Chain | 3 (6) | 3 (8) | - | |
|
| ||||
| Mayo criteria 20-2-20 | ||||
| Low | 21 (41) | 17 (42) | 4 (36) | 0.47 |
| Intermediate | 15 (29) | 10 (25) | 5 (45) | |
| High | 15 (29) | 13 (32) | 2 (18) | |
|
| ||||
| Cytogenetics, FISH | ||||
| t(4;14) | ||||
| Yes | 6 (12) | 4 (10) | 2 (18) | |
| t(14;16) | ||||
| Yes | 2 (4) | 1 (2) | 1 (9) | |
| 17p deletion | ||||
| Yes | 4 (8) | 3 (8) | 1 (9) | |
| +1q amplification | ||||
| Yes | 11 (22) | 9 (22) | 2 (18) | |
|
| ||||
| High-risk cytogenetics | ||||
| No | 30 (59) | 25 (62) | 5 (45) | 0.70 |
| Yes | 17 (33) | 13 (32) | 4 (36) | |