Table 2:
Highest grade toxicity experienced on treatment for n=51 patients. AEs grade 2+ in at least 10% of patients and all grade 4+.
| Worst grade |
|||||
|---|---|---|---|---|---|
| Total N=51 | 2 - Moderate | 3 - Severe | 4 - Life Threatening | 5 - Fatal | |
|
| |||||
| Upper respiratory infection | 22 (43) | 21 (41) | 1 (2) | - | - |
| Fatigue | 21 (41) | 18 (35) | 3 (6) | - | - |
| Hypophosphatemia | 21 (41) | 2 (4) | 16 (31) | 3 (6) | - |
| Neutropenia | 15 (29) | 2 (4) | 12 (24) | 1 (2) | - |
| Lymphocytopenia | 14 (27) | 3 (6) | 11 (22) | - | - |
| Hyperglycemia | 12 (24) | 9 (18) | 2 (4) | 1 (2) | - |
| Constipation | 10 (20) | 9 (18) | 1 (2) | - | - |
| Cytopenia | 10 (20) | 8 (16) | 2 (4) | - | - |
| Diarrhea | 10 (20) | 8 (16) | 2 (4) | - | - |
| Anemia | 8 (16) | 7 (14) | 1 (2) | - | - |
| Lung infection | 8 (16) | 3 (6) | 5 (10) | - | - |
| Hypertension | 7 (14) | 4 (8) | 3 (6) | - | - |
| Insomnia | 7 (14) | 6 (12) | 1 (2) | - | - |
| Thrombocytopenia | 7 (14) | 4 (8) | 2 (4) | 1 (2) | - |
| Rash maculopapular | 6 (12) | 4 (8) | 2 (4) | - | - |
| Cataract | 1 (2) | - | - | 1 (2) | - |
| Cholecystitis | 1 (2) | - | - | 1 (2) | - |
| Diabetic ketoacidosis | 1 (2) | - | - | 1 (2) | - |
| Lymphocytosis | 1 (2) | - | - | 1 (2) | - |
| Myocardial infarction | 1 (2) | - | - | - | 1 (2) |
| Sepsis | 1 (2) | - | - | - | 1 (2) |