Table 7. Univariate and multivariate Cox regression models for predicting overall survival.
| Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Age ≤50 years | 0.785 | [0.252–2.439] | 0.675 | |||
| Gender, male | 0.606 | [0.191–1.919] | 0.394 | |||
| Tumor size >2 cm | 4.385 | [1.375–13.989] | 0.012 | 2.847 | [0.870–9.312] | 0.084 |
| Multifocality | 1.536 | [0.458–5.146] | 0.487 | |||
| Extrathyroidal extension | 2.965 | [0.887–9.908] | 0.077 | |||
| Bilateral | 0.649 | [0.083–5.095] | 0.681 | |||
| Preoperative calcitonin ≤300 ng/L | 6.943 | [0.881–54.724] | 0.066 | |||
| Pathologic T classification, pT3/T4 | 2.801 | [0.838–9.361] | 0.094 | |||
| Pathologic N classification, pN0/N1a | 14.947 | [1.922–116.264] | 0.010 | 4.521 | [0.516–39.627] | 0.173 |
| Resected lymph nodes ≤10 | 64.123 | [0.597–6890.514] | 0.081 | |||
| Metastasized lymph nodes ≤10 | 3.251 | [0.971–10.884] | 0.056 | |||
| Lymph node ratio ≤0.24 | 15.994 | [2.063–124.023] | 0.008 | 10.061 | [1.222–82.841] | 0.032 |
| AJCC clinical stage, III/IV stages | 43.503 | [0.332–5694.725] | 0.129 | |||
| Biochemical cure | 1.870 | [0.467–7.488] | 0.376 | |||
Notes:
HR, hazard ratio; CI, confidence interval. The bold part of the P value represents P < 0.05.