Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Apr;29(4):473–488. doi: 10.1261/rna.079497.122

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 Bagnolini et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article, published in RNA, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

FIGURE 5. — (A) Secondary structures of HIV RNAs screened with DMA library. (TAR) Trans-activation response element, (RRE) rev response element, (FSS) frameshift-stimulating, (ESSV) exonic splicing silencer of Vpr. (B) Linear discriminate analysis (LDA) plot based on 20 cheminformatic parameters clusters to differentiate five groups of ligands for HIV RNA targets. (C) LDA loading plot for the qualitative analysis of the contribution of each cheminformatic parameter contributing on F1 versus F2. (MW) Molecular weight, (HBA) number of hydrogen bond acceptors, (HBD) number of hydrogen bond donors, (LogP) n-octanol/water partition coefficient, (RotB) number of rotatable bonds, (tPSA) topological polar surface area, (LogD) n-octanol/water distribution coefficient, (N) number of nitrogen atoms, (O) number of oxygen atoms, (Rings) number of rings, (ArRings) number of aromatic rings, (HetRings) number of heteroatom-containing rings, (SysRings) number of ring systems, (SysRR) ring complexity, (Fsp³) fraction of sp³ hybridized carbons, (ASA) accessible surface area, (relPSA) relative polar surface area, (VWSA) van der Waals surface area (panels A–C adapted with permission from Patwardhan et al. 2019b, © Royal Society of Chemistry).