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. Author manuscript; available in PMC: 2023 Mar 16.
Published in final edited form as: Brain Behav Immun. 2022 Dec 19;108:279–291. doi: 10.1016/j.bbi.2022.12.013

Fig. 2. Intermittent LPS Regimen Reliably Induces Moderate Sickness Behavior.

Fig. 2.

At 4 h following each injection, LPS exposure induced significantly elevated sickness behavior relative to Vehicle-treated mice. Within group comparisons across time in a given injection cycle revealed that LPS-treated mice made complete recoveries by 14 days following all five exposures, as evidenced by significantly lower sickness behavior scores at Day 14 than at 4 h post-injection. With the exception of the Injection 3 cycle, Vehicle-treated mice showed no changes in health/sickness scores across time within a given injection cycle. Mean ± SEM; * = p < 0.05; ** = p < 0.0001. Vehicle (N = 46) =; Intermittent LPS (N = 43) =.