. Author manuscript; available in PMC: 2023 Mar 16.

Published in final edited form as: Brain Behav Immun. 2022 Dec 19;108:279–291. doi: 10.1016/j.bbi.2022.12.013

Table 1.

Cytokine gene expression in cognitive brain regions (Mean ± SEM; relative fold change).

Behaviorally Naïve Mice

TNF-α

OSM

LIF

CCL2

IL-1β

GFAP

IL-6

Veh

LPS

Veh

LPS

Veh

LPS

Veh

LPS

Veh

LPS

Veh

LPS

Veh

LPS

Cortex

1.08 ± 0.30

1.04 ± 0.08

1.01 ± 0.09

0.90 ± 0.09

1.09 ± 0.32

0.83 ± 0.23

1.07 ± 0.25

0.90 ± 0.08

1.02 ± 0.12

0.89 ± 0.18

1.02 ± 0.14

1.03 ± 0.24

1.05 ± 0.22

1.14 ± 0.17

Hippocampus

1.09 ± 0.34

1.09 ± 0.09

1.02 ± 0.12

0.93 ± 0.14

1.14 ± 0.36

0.95 ± 0.22

1.04 ± 0.21

0.55 ± 0.04

1.02 ± 0.16

0.54 ± 0.04^*

1.01 ± 0.08

1.21 ± 0.09

1.02 ± 0.13

1.25 ± 0.14

Behaviorally Tested Mice

TNF-α

OSM

LIF

CCL2

IL-1β

GFAP

IL-6

Veh

LPS

Veh

LPS

Veh

LPS

Veh

LPS

Veh

LPS

Veh

LPS

Veh

LPS

Cortex

1.04 ± 0.15

1.15 ± 0.21

1.02 ± 0.10

1.20 ± 0.06

1.03 ± 0.14

0.72 ± 0.20

1.04 ± 0.17

0.95 ± 0.10

1.05 ± 0.17

1.18 ± 0.17

1.01 ± 0.09

1.10 ± 0.13

1.02 ± 0.10

0.89 ± 0.07

Hippocampus

1.05 ± 0.18

1.55 ± 0.41

1.00 ± 0.06

0.96 ± 0.09

1.12 ± 0.33

1.49 ± 0.32

1.03 ± 0.16

0.97 ± 0.02

1.04 ± 0.15

1.70 ± 0.40

1.00 ± 0.04

0.96 ± 0.03

1.02 ± 0.11

1.26 ± 0.08

All Mice (Naïve & Tested)

TNF-α

OSM

LIF

CCL2

IL-1β

GFAP

IL-6

Veh

LPS

Veh

LPS

Veh

LPS

Veh

LPS

Veh

LPS

Veh

LPS

Veh

LPS

Cortex

1.07 ± 0.16

1.10 ± 0.11

1.05 ± 0.13

1.07 ± 0.08

1.07 ± 0.17

0.79 ± 0.16

1.07 ± 0.17

0.94 ± 0.08

1.04 ± 0.11

1.06 ± 0.13

1.03 ± 0.11

1.08 ± 0.14

1.03 ± 0.10

1.00 ± 0.10

Hippocampus

0.99 ± 0.16

1.22 ± 0.17

1.00 ± 0.06

0.95 ± 0.07

1.14 ± 0.23

1.22 ± 0.18

1.09 ± 0.19

1.56 ± 0.28

1.07 ± 0.15

1.04 ± 0.21

1.00 ± 0.04

1.08 ± 0.06

1.02 ± 0.08

1.26 ± 0.07^*

= p < 0.05.