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. 2023 Feb 18;78(5):1017–1027. doi: 10.1016/j.jhep.2023.02.007

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© 2023 The Author(s)

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Fig. 1 — Impaired adaptive effector response in LTRs vs. HCs after three doses of mRNA vaccination.

(A) Spike-specific IgG-levels in HCs and LTRs after the 3^rd vaccine dose (LTRs n = 16, HCs n = 14). (B) Numbers of CD8+ T-cell responses to spike-OLPs after in vitro expansion per patient after the 3^rd vaccine dose (HCs n = 9; LTRs n = 9). (C) Number and location of CD8+ T-cell responses to spike-OLPs after in vitro expansion in HCs (top) vs. LTRs (bottom) after the 3^rd vaccine dose. Numbers of tested individuals (per HLA allotype and in total) are indicated. OLPs with >1 HLA-matched previously described epitopes are crosshatched. (D) Ex vivo frequency of spike-specific CD8+ T cells in HCs and LTRs after the 3^rd vaccine dose (HCs n = 12; LTRs n = 11). Cut-off for positive responses is indicated by a dashed line. Statistics: Mann-Whitney U test (A, B, D). HCs, healthy controls; LTRs, liver transplant recipients; OLPs, overlapping peptides.